node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIB4 | FAM181B | ENSP00000288861 | ENSP00000365295 | Calcium and integrin binding family member 4. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.434 |
FAM181B | CIB4 | ENSP00000365295 | ENSP00000288861 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Calcium and integrin binding family member 4. | 0.434 |
FAM181B | FHAD1 | ENSP00000365295 | ENSP00000351770 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1. | 0.451 |
FAM181B | NABP1 | ENSP00000365295 | ENSP00000403683 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.500 |
FAM181B | PRCP | ENSP00000365295 | ENSP00000377055 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. | 0.509 |
FAM181B | PRSS23 | ENSP00000365295 | ENSP00000280258 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Serine protease 23; Belongs to the peptidase S1 family. | 0.434 |
FAM181B | TEAD4 | ENSP00000365295 | ENSP00000352926 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | 0.901 |
FAM181B | TMEM101 | ENSP00000365295 | ENSP00000468025 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Transmembrane protein 101; May activate NF-kappa-B signaling pathways. | 0.477 |
FAM181B | WFDC10B | ENSP00000365295 | ENSP00000337466 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Protein WFDC10B; WAP four-disulfide core domain 10B. | 0.471 |
FAM181B | ZNF536 | ENSP00000365295 | ENSP00000347730 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.523 |
FHAD1 | FAM181B | ENSP00000351770 | ENSP00000365295 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.451 |
FHAD1 | TMEM101 | ENSP00000351770 | ENSP00000468025 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1. | Transmembrane protein 101; May activate NF-kappa-B signaling pathways. | 0.411 |
NABP1 | FAM181B | ENSP00000403683 | ENSP00000365295 | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.500 |
PRCP | FAM181B | ENSP00000377055 | ENSP00000365295 | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.509 |
PRSS23 | FAM181B | ENSP00000280258 | ENSP00000365295 | Serine protease 23; Belongs to the peptidase S1 family. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.434 |
TEAD4 | FAM181B | ENSP00000352926 | ENSP00000365295 | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.901 |
TMEM101 | FAM181B | ENSP00000468025 | ENSP00000365295 | Transmembrane protein 101; May activate NF-kappa-B signaling pathways. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.477 |
TMEM101 | FHAD1 | ENSP00000468025 | ENSP00000351770 | Transmembrane protein 101; May activate NF-kappa-B signaling pathways. | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1. | 0.411 |
WFDC10B | FAM181B | ENSP00000337466 | ENSP00000365295 | Protein WFDC10B; WAP four-disulfide core domain 10B. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.471 |
ZNF536 | FAM181B | ENSP00000347730 | ENSP00000365295 | Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'; Belongs to the krueppel C2H2-type zinc-finger protein family. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.523 |