node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCHCR1 | CDSN | ENSP00000379566 | ENSP00000365465 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.921 |
CCHCR1 | HLA-C | ENSP00000379566 | ENSP00000365402 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | 0.852 |
CCHCR1 | PSORS1C1 | ENSP00000379566 | ENSP00000259881 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Psoriasis susceptibility 1 candidate 1. | 0.645 |
CDSN | CCHCR1 | ENSP00000365465 | ENSP00000379566 | Corneodesmosin; Important for the epidermal barrier integrity. | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | 0.921 |
CDSN | DSC1 | ENSP00000365465 | ENSP00000257198 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.997 |
CDSN | DSG1 | ENSP00000365465 | ENSP00000257192 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.995 |
CDSN | HLA-C | ENSP00000365465 | ENSP00000365402 | Corneodesmosin; Important for the epidermal barrier integrity. | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | 0.845 |
CDSN | KLK7 | ENSP00000365465 | ENSP00000470538 | Corneodesmosin; Important for the epidermal barrier integrity. | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | 0.876 |
CDSN | LCE2B | ENSP00000365465 | ENSP00000357769 | Corneodesmosin; Important for the epidermal barrier integrity. | Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum. | 0.873 |
CDSN | LCE3D | ENSP00000365465 | ENSP00000357776 | Corneodesmosin; Important for the epidermal barrier integrity. | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. | 0.837 |
CDSN | LOR | ENSP00000365465 | ENSP00000357731 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.933 |
CDSN | PSORS1C1 | ENSP00000365465 | ENSP00000259881 | Corneodesmosin; Important for the epidermal barrier integrity. | Psoriasis susceptibility 1 candidate 1. | 0.946 |
CDSN | SPRR2G | ENSP00000365465 | ENSP00000357737 | Corneodesmosin; Important for the epidermal barrier integrity. | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.831 |
DSC1 | CDSN | ENSP00000257198 | ENSP00000365465 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.997 |
DSC1 | DSG1 | ENSP00000257198 | ENSP00000257192 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.998 |
DSC1 | KLK7 | ENSP00000257198 | ENSP00000470538 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | 0.688 |
DSC1 | LOR | ENSP00000257198 | ENSP00000357731 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Loricrin; Major keratinocyte cell envelope protein. | 0.832 |
DSC1 | SPRR2G | ENSP00000257198 | ENSP00000357737 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.610 |
DSG1 | CDSN | ENSP00000257192 | ENSP00000365465 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.995 |
DSG1 | DSC1 | ENSP00000257192 | ENSP00000257198 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.998 |