node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C22orf23 | C2CD6 | ENSP00000384667 | ENSP00000409937 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | 0.540 |
C22orf23 | GKAP1 | ENSP00000384667 | ENSP00000365550 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.507 |
C22orf23 | TSACC | ENSP00000384667 | ENSP00000357238 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. | 0.663 |
C2CD6 | C22orf23 | ENSP00000409937 | ENSP00000384667 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | 0.540 |
C2CD6 | GKAP1 | ENSP00000409937 | ENSP00000365550 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.480 |
C2CD6 | TSACC | ENSP00000409937 | ENSP00000357238 | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. | 0.568 |
C9orf64 | GKAP1 | ENSP00000365522 | ENSP00000365550 | Queuosine salvage protein; Involved in salvaging queuosine. | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.557 |
C9orf64 | KIF27 | ENSP00000365522 | ENSP00000297814 | Queuosine salvage protein; Involved in salvaging queuosine. | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis. | 0.628 |
GKAP1 | C22orf23 | ENSP00000365550 | ENSP00000384667 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | UPF0193 protein EVG1; Chromosome 22 open reading frame 23. | 0.507 |
GKAP1 | C2CD6 | ENSP00000365550 | ENSP00000409937 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. | 0.480 |
GKAP1 | C9orf64 | ENSP00000365550 | ENSP00000365522 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | Queuosine salvage protein; Involved in salvaging queuosine. | 0.557 |
GKAP1 | IRS1 | ENSP00000365550 | ENSP00000304895 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). | 0.495 |
GKAP1 | ITGA2B | ENSP00000365550 | ENSP00000262407 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. | 0.549 |
GKAP1 | KIF27 | ENSP00000365550 | ENSP00000297814 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis. | 0.643 |
GKAP1 | PRKG1 | ENSP00000365550 | ENSP00000363092 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] | 0.875 |
GKAP1 | TSACC | ENSP00000365550 | ENSP00000357238 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. | 0.522 |
GKAP1 | UBQLN1 | ENSP00000365550 | ENSP00000365576 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] | 0.483 |
GKAP1 | VWF | ENSP00000365550 | ENSP00000261405 | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | Von Willebrand antigen 2; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.495 |
IRS1 | GKAP1 | ENSP00000304895 | ENSP00000365550 | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.495 |
ITGA2B | GKAP1 | ENSP00000262407 | ENSP00000365550 | Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. | G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. | 0.549 |