node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCZ1 | CCZ1B | ENSP00000325681 | ENSP00000314544 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | 0.968 |
CCZ1 | EEA1 | ENSP00000325681 | ENSP00000317955 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | 0.701 |
CCZ1 | GRIPAP1 | ENSP00000325681 | ENSP00000365606 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). | 0.677 |
CCZ1 | VPS39 | ENSP00000325681 | ENSP00000335193 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. | 0.957 |
CCZ1 | VPS41 | ENSP00000325681 | ENSP00000309457 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] | 0.929 |
CCZ1B | CCZ1 | ENSP00000314544 | ENSP00000325681 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | 0.968 |
CCZ1B | EEA1 | ENSP00000314544 | ENSP00000317955 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | 0.697 |
CCZ1B | GRIPAP1 | ENSP00000314544 | ENSP00000365606 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). | 0.685 |
CCZ1B | VPS39 | ENSP00000314544 | ENSP00000335193 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. | 0.957 |
CCZ1B | VPS41 | ENSP00000314544 | ENSP00000309457 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] | 0.928 |
EEA1 | CCZ1 | ENSP00000317955 | ENSP00000325681 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | 0.701 |
EEA1 | CCZ1B | ENSP00000317955 | ENSP00000314544 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | 0.697 |
EEA1 | GRIP1 | ENSP00000317955 | ENSP00000381098 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.509 |
EEA1 | GRIP2 | ENSP00000317955 | ENSP00000478352 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. | 0.550 |
EEA1 | GRIPAP1 | ENSP00000317955 | ENSP00000365606 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). | 0.754 |
EEA1 | RAB4A | ENSP00000317955 | ENSP00000355651 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | Ras-related protein Rab-4A; Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. | 0.860 |
EEA1 | RALGDS | ENSP00000317955 | ENSP00000361120 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | Ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. | 0.429 |
EEA1 | VPS39 | ENSP00000317955 | ENSP00000335193 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. | 0.496 |
GRIP1 | EEA1 | ENSP00000381098 | ENSP00000317955 | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | 0.509 |
GRIP1 | GRIP2 | ENSP00000381098 | ENSP00000478352 | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. | 0.556 |