TBC1D8 protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC16	TBC1D16	ENSP00000348554	ENSP00000309794	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).	0.592
CDC16	TBC1D17	ENSP00000348554	ENSP00000221543	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known.	0.491
CDC16	TBC1D20	ENSP00000348554	ENSP00000346139	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.	0.865
CDC16	TBC1D5	ENSP00000348554	ENSP00000402935	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	TBC1 domain family member 5; May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogrammin [...]	0.576
CDC16	TBC1D8	ENSP00000348554	ENSP00000386856	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s).	0.540
CDC16	TBC1D8B	ENSP00000348554	ENSP00000349781	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	TBC1 domain family member 8B; Involved in vesicular recycling, probably as a RAB11B GTPase- activating protein.	0.495
TBC1D16	CDC16	ENSP00000309794	ENSP00000348554	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	0.592
TBC1D16	TBC1D19	ENSP00000309794	ENSP00000264866	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	0.628
TBC1D16	TBC1D20	ENSP00000309794	ENSP00000346139	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.	0.536
TBC1D16	TBC1D8	ENSP00000309794	ENSP00000386856	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s).	0.569
TBC1D17	CDC16	ENSP00000221543	ENSP00000348554	TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known.	Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC6/CDC16 family.	0.491
TBC1D17	TBC1D19	ENSP00000221543	ENSP00000264866	TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known.	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	0.555
TBC1D17	TBC1D20	ENSP00000221543	ENSP00000346139	TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known.	TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.	0.526
TBC1D17	TBC1D8	ENSP00000221543	ENSP00000386856	TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known.	TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s).	0.522
TBC1D19	TBC1D16	ENSP00000264866	ENSP00000309794	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).	0.628
TBC1D19	TBC1D17	ENSP00000264866	ENSP00000221543	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known.	0.555
TBC1D19	TBC1D20	ENSP00000264866	ENSP00000346139	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.	0.566
TBC1D19	TBC1D21	ENSP00000264866	ENSP00000300504	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity.	0.632
TBC1D19	TBC1D22A	ENSP00000264866	ENSP00000336724	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s).	0.540
TBC1D19	TBC1D22B	ENSP00000264866	ENSP00000362590	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).	TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s).	0.638