node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDN1 | EDN2 | ENSP00000368683 | ENSP00000361668 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.836 |
EDN1 | EDN3 | ENSP00000368683 | ENSP00000337128 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.848 |
EDN1 | EDNRB | ENSP00000368683 | ENSP00000366416 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | 0.999 |
EDN1 | GNA11 | ENSP00000368683 | ENSP00000078429 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C; G protein subunits alpha, group q | 0.922 |
EDN1 | GNA14 | ENSP00000368683 | ENSP00000365807 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G protein subunits alpha, group q | 0.900 |
EDN1 | GNAI2 | ENSP00000368683 | ENSP00000312999 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division | 0.910 |
EDN1 | GNAO1 | ENSP00000368683 | ENSP00000262494 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.912 |
EDN1 | GNAQ | ENSP00000368683 | ENSP00000286548 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity); Belongs to the G-alpha family. G(q) subfamily | 0.963 |
EDN1 | PLCB1 | ENSP00000368683 | ENSP00000338185 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes; C2 domain containing phospholipases | 0.930 |
EDN1 | SLC9A3 | ENSP00000368683 | ENSP00000264938 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Solute carriers | 0.937 |
EDN2 | EDN1 | ENSP00000361668 | ENSP00000368683 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.836 |
EDN2 | EDN3 | ENSP00000361668 | ENSP00000337128 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.841 |
EDN2 | EDNRB | ENSP00000361668 | ENSP00000366416 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | 0.991 |
EDN3 | EDN1 | ENSP00000337128 | ENSP00000368683 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.848 |
EDN3 | EDN2 | ENSP00000337128 | ENSP00000361668 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.841 |
EDN3 | EDNRB | ENSP00000337128 | ENSP00000366416 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | 0.999 |
EDNRB | EDN1 | ENSP00000366416 | ENSP00000368683 | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.999 |
EDNRB | EDN2 | ENSP00000366416 | ENSP00000361668 | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.991 |
EDNRB | EDN3 | ENSP00000366416 | ENSP00000337128 | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.999 |
EDNRB | GNA11 | ENSP00000366416 | ENSP00000078429 | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C; G protein subunits alpha, group q | 0.964 |