STRINGSTRING
FXN protein (human) - STRING interaction network
"FXN" - Frataxin in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FXNFrataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] (210 aa)    
Predicted Functional Partners:
NFS1
NFS1 nitrogen fixation 1 homolog (S. cerevisiae); Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (457 aa)
     
  0.998
LYRM4
LYR motif containing 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis (130 aa)
     
  0.993
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (235 aa)
     
 
  0.991
ISCU
Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed-11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apop [...] (167 aa)
     
 
  0.987
ACO2
Aconitase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (780 aa)
       
  0.981
HSPA9
Heat shock 70kDa protein 9 (mortalin); Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone (679 aa)
       
  0.979
PMPCB
Peptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (489 aa)
     
  0.975
FDX1
Ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (184 aa)
     
 
  0.963
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (429 aa)
     
  0.960
FDX1L
Ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis (183 aa)
     
 
  0.955
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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