| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP12 | TMEM252 | ENSP00000384537 | ENSP00000366528 | A-kinase anchor protein 12; Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). | Transmembrane protein 252. | 0.448 |
| BAG3 | TMEM252 | ENSP00000358081 | ENSP00000366528 | BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti- apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. | Transmembrane protein 252. | 0.457 |
| CNDP1 | TMEM252 | ENSP00000351682 | ENSP00000366528 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Transmembrane protein 252. | 0.443 |
| KRTAP4-8 | NMS | ENSP00000328444 | ENSP00000366061 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | 0.656 |
| KRTAP4-8 | OR6A2 | ENSP00000328444 | ENSP00000492990 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.489 |
| KRTAP4-8 | SFTA3 | ENSP00000328444 | ENSP00000428331 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. | 0.559 |
| KRTAP4-8 | TAC4 | ENSP00000328444 | ENSP00000334042 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. | 0.630 |
| KRTAP4-8 | TMEM252 | ENSP00000328444 | ENSP00000366528 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Transmembrane protein 252. | 0.540 |
| NMS | KRTAP4-8 | ENSP00000366061 | ENSP00000328444 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.656 |
| NMS | OR6A2 | ENSP00000366061 | ENSP00000492990 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.491 |
| NMS | SFTA3 | ENSP00000366061 | ENSP00000428331 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. | 0.430 |
| NMS | TAC4 | ENSP00000366061 | ENSP00000334042 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. | 0.614 |
| NMS | TMEM252 | ENSP00000366061 | ENSP00000366528 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | Transmembrane protein 252. | 0.484 |
| OR6A2 | KRTAP4-8 | ENSP00000492990 | ENSP00000328444 | Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.489 |
| OR6A2 | NMS | ENSP00000492990 | ENSP00000366061 | Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | 0.491 |
| OR6A2 | TAC4 | ENSP00000492990 | ENSP00000334042 | Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. | 0.667 |
| OR6A2 | TMEM252 | ENSP00000492990 | ENSP00000366528 | Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Transmembrane protein 252. | 0.505 |
| PHACTR4 | TMEM252 | ENSP00000362942 | ENSP00000366528 | Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to [...] | Transmembrane protein 252. | 0.460 |
| SFTA3 | KRTAP4-8 | ENSP00000428331 | ENSP00000328444 | Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.559 |
| SFTA3 | NMS | ENSP00000428331 | ENSP00000366061 | Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family. | 0.430 |
