STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBWD6COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. (395 aa)    
Predicted Functional Partners:
CBWD2
COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  
 
0.828
CBWD1
COBW domain containing 1.
  
 
0.626
ANKRD20A3
Ankyrin repeat domain-containing protein 20A3.
   
  
 0.550
SETD2
Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair [...]
      
 0.549
FAM72C
Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family.
      
 0.490
ANKRD20A2
Ankyrin repeat domain-containing protein 20A2.
   
  
 0.486
ANKRD20A4
Ankyrin repeat domain-containing protein 20A4.
   
  
 0.484
FAM72B
Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.
      
 0.483
MRPL33
Mitochondrial ribosomal protein L33.
  
  
 0.482
DTWD2
DTW domain containing 2.
    
   0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.