FAM216A protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC7	FAM216A	ENSP00000394394	ENSP00000366901	Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC7 family.	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	0.504
ANAPC7	GPN3	ENSP00000394394	ENSP00000442770	Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC7 family.	GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	0.514
DIP2B	FAM216A	ENSP00000301180	ENSP00000366901	Disco interacting protein 2 homolog B.	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	0.487
DIP2B	SERF2	ENSP00000301180	ENSP00000387187	Disco interacting protein 2 homolog B.	Small EDRK-rich factor 2; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates. Belongs to the SERF family.	0.446
DIP2B	TMEM134	ENSP00000301180	ENSP00000312615	Disco interacting protein 2 homolog B.	Transmembrane protein 134.	0.473
FAM216A	ANAPC7	ENSP00000366901	ENSP00000394394	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC7 family.	0.504
FAM216A	DIP2B	ENSP00000366901	ENSP00000301180	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Disco interacting protein 2 homolog B.	0.487
FAM216A	GPN3	ENSP00000366901	ENSP00000442770	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	0.670
FAM216A	LAGE3	ENSP00000366901	ENSP00000349923	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex; Belongs to the CTAG/PCC1 family.	0.478
FAM216A	MAGEA10	ENSP00000366901	ENSP00000244096	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	0.913
FAM216A	NYNRIN	ENSP00000366901	ENSP00000371994	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Protein NYNRIN; NYN domain and retroviral integrase containing.	0.445
FAM216A	SERF2	ENSP00000366901	ENSP00000387187	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Small EDRK-rich factor 2; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates. Belongs to the SERF family.	0.450
FAM216A	SMYD4	ENSP00000366901	ENSP00000304360	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily.	0.448
FAM216A	TMEM134	ENSP00000366901	ENSP00000312615	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Transmembrane protein 134.	0.530
FAM216A	V9GZ13_HUMAN	ENSP00000366901	ENSP00000477297	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	Uncharacterized protein.	0.553
GPN3	ANAPC7	ENSP00000442770	ENSP00000394394	GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC7 family.	0.514
GPN3	FAM216A	ENSP00000442770	ENSP00000366901	GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	0.670
GPN3	V9GZ13_HUMAN	ENSP00000442770	ENSP00000477297	GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	Uncharacterized protein.	0.439
LAGE3	FAM216A	ENSP00000349923	ENSP00000366901	EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex; Belongs to the CTAG/PCC1 family.	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	0.478
MAGEA10	FAM216A	ENSP00000244096	ENSP00000366901	Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.	0.913