Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KRT40Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family. (431 aa)    
Predicted Functional Partners:
KRT33A
Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family.
  
 
0.929
KRT34
Keratin, type I cuticular Ha4; Keratin 34.
  
 
0.926
KRT6A
Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family.
    
 
0.823
KRT33B
Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.
  
 
0.802
KRT31
Keratin, type I cuticular Ha1; Keratin 31.
  
 
0.799
KRT2
Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
    
 
0.799
ATPAF2
ATP synthase mitochondrial F1 complex assembly factor 2; May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase); Belongs to the ATP12 family.
    
   0.773
TNIP3
TNFAIP3-interacting protein 3; Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
    
 
 0.741
KRT32
Keratin, type I cuticular Ha2; Keratin 32; Belongs to the intermediate filament family.
  
 
0.698
KRT82
Keratin, type II cuticular Hb2; Keratin 82; Belongs to the intermediate filament family.
  
 
0.667
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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