STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H4C3H4 clustered histone 3. (103 aa)    
Predicted Functional Partners:
H2AC4
H2A clustered histone 4.
 
 
 0.991
H2AC8
Histone H2A type 1-B/E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.990
H3C2
H3 clustered histone 2.
 
 
 
 0.986
H3C10
H3 clustered histone 10.
 
 
 
 0.983
H3C4
H3 clustered histone 4.
 
 
 
 0.983
H3C1
H3 clustered histone 1.
 
 
 
 0.983
H3C11
H3 clustered histone 11.
 
 
 
 0.983
H3C7
H3 clustered histone 7.
 
 
 
 0.983
H3C8
H3 clustered histone 8.
 
 
 
 0.983
H4C2
H4 clustered histone 2.
  
0.981
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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