LYPD5 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL37	KLK8	ENSP00000263326	ENSP00000375682	Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation; Belongs to the IL-1 family.	Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]	0.408
IL37	LYPD5	ENSP00000263326	ENSP00000367185	Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation; Belongs to the IL-1 family.	LY6/PLAUR domain containing 5.	0.608
KLK8	IL37	ENSP00000375682	ENSP00000263326	Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]	Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation; Belongs to the IL-1 family.	0.408
KLK8	LYPD5	ENSP00000375682	ENSP00000367185	Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]	LY6/PLAUR domain containing 5.	0.761
KLK8	SLURP1	ENSP00000375682	ENSP00000246515	Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]	Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have an immunomodulatory functi [...]	0.592
KLK8	WFDC12	ENSP00000375682	ENSP00000361871	Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor.	0.693
LY6G6D	LY6L	ENSP00000364985	ENSP00000455811	Lymphocyte antigen 6 family member G6D.	Lymphocyte antigen 6 family member L.	0.442
LY6G6D	LYPD5	ENSP00000364985	ENSP00000367185	Lymphocyte antigen 6 family member G6D.	LY6/PLAUR domain containing 5.	0.590
LY6L	LY6G6D	ENSP00000455811	ENSP00000364985	Lymphocyte antigen 6 family member L.	Lymphocyte antigen 6 family member G6D.	0.442
LY6L	LYPD5	ENSP00000455811	ENSP00000367185	Lymphocyte antigen 6 family member L.	LY6/PLAUR domain containing 5.	0.656
LY6L	PATE2	ENSP00000455811	ENSP00000351325	Lymphocyte antigen 6 family member L.	Prostate and testis expressed 2.	0.720
LY6L	PATE3	ENSP00000455811	ENSP00000395505	Lymphocyte antigen 6 family member L.	Prostate and testis expressed 3; Belongs to the PATE family.	0.753
LY6L	PINLYP	ENSP00000455811	ENSP00000479240	Lymphocyte antigen 6 family member L.	Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family.	0.686
LY6L	SLURP1	ENSP00000455811	ENSP00000246515	Lymphocyte antigen 6 family member L.	Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have an immunomodulatory functi [...]	0.496
LYPD5	IL37	ENSP00000367185	ENSP00000263326	LY6/PLAUR domain containing 5.	Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation; Belongs to the IL-1 family.	0.608
LYPD5	KLK8	ENSP00000367185	ENSP00000375682	LY6/PLAUR domain containing 5.	Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]	0.761
LYPD5	LY6G6D	ENSP00000367185	ENSP00000364985	LY6/PLAUR domain containing 5.	Lymphocyte antigen 6 family member G6D.	0.590
LYPD5	LY6L	ENSP00000367185	ENSP00000455811	LY6/PLAUR domain containing 5.	Lymphocyte antigen 6 family member L.	0.656
LYPD5	PATE2	ENSP00000367185	ENSP00000351325	LY6/PLAUR domain containing 5.	Prostate and testis expressed 2.	0.569
LYPD5	PATE3	ENSP00000367185	ENSP00000395505	LY6/PLAUR domain containing 5.	Prostate and testis expressed 3; Belongs to the PATE family.	0.607