node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFGAP2 | MLF2 | ENSP00000434442 | ENSP00000203630 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Myeloid leukemia factor 2 | 0.842 |
ARFGAP2 | SCGN | ENSP00000434442 | ENSP00000367197 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | 0.655 |
ARFGAP2 | SNAP23 | ENSP00000434442 | ENSP00000249647 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.703 |
DHX57 | KIF13A | ENSP00000405111 | ENSP00000259711 | Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily | Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycli [...] | 0.716 |
DHX57 | SCGN | ENSP00000405111 | ENSP00000367197 | Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | 0.690 |
KIF13A | DHX57 | ENSP00000259711 | ENSP00000405111 | Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycli [...] | Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily | 0.716 |
KIF13A | SCGN | ENSP00000259711 | ENSP00000367197 | Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycli [...] | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | 0.676 |
LRRC16A | SCGN | ENSP00000331983 | ENSP00000367197 | F-actin-uncapping protein LRRC16A; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration; Belongs to the CARMIL family | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | 0.640 |
MLF2 | ARFGAP2 | ENSP00000203630 | ENSP00000434442 | Myeloid leukemia factor 2 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | 0.842 |
MLF2 | SCGN | ENSP00000203630 | ENSP00000367197 | Myeloid leukemia factor 2 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | 0.631 |
MLF2 | SNAP23 | ENSP00000203630 | ENSP00000249647 | Myeloid leukemia factor 2 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.681 |
MYH10 | SCGN | ENSP00000353590 | ENSP00000367197 | Myosin heavy chain 9/10/11/14; Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | 0.621 |
SCGN | ARFGAP2 | ENSP00000367197 | ENSP00000434442 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | 0.655 |
SCGN | DHX57 | ENSP00000367197 | ENSP00000405111 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily | 0.690 |
SCGN | KIF13A | ENSP00000367197 | ENSP00000259711 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycli [...] | 0.676 |
SCGN | LRRC16A | ENSP00000367197 | ENSP00000331983 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | F-actin-uncapping protein LRRC16A; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration; Belongs to the CARMIL family | 0.640 |
SCGN | MLF2 | ENSP00000367197 | ENSP00000203630 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | Myeloid leukemia factor 2 | 0.631 |
SCGN | MYH10 | ENSP00000367197 | ENSP00000353590 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | Myosin heavy chain 9/10/11/14; Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.621 |
SCGN | SNAP23 | ENSP00000367197 | ENSP00000249647 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family | 0.949 |
SCGN | SNAP25 | ENSP00000367197 | ENSP00000254976 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.995 |