STRINGSTRING
TMEM8B protein (human) - STRING interaction network
"TMEM8B" - Transmembrane protein 8B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM8BTransmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (472 aa)    
Predicted Functional Partners:
FOXRED2
FAD-dependent oxidoreductase domain containing 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (684 aa)
     
   
  0.536
PIGZ
Phosphatidylinositol glycan anchor biosynthesis, class Z; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues (579 aa)
           
  0.533
EGR1
Early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (543 aa)
           
  0.471
PRPSAP1
Phosphoribosyl pyrophosphate synthetase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis (385 aa)
           
  0.442
PRPSAP2
Phosphoribosyl pyrophosphate synthetase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis (369 aa)
           
  0.442
NPRL3
Nitrogen permease regulator-like 3 (S. cerevisiae); As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (568 aa)
           
  0.418
BRD7
Bromodomain containing 7; Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at ’Tyr-216’. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at ’Lys-9’ (H3K9ac). Binds to the ESR1 promoter. Recrui [...] (652 aa)
           
  0.408
MXRA7
Matrix-remodelling associated 7 (204 aa)
           
  0.404
TMEM57
Transmembrane protein 57 (664 aa)
           
  0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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