STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RCBTB1RCC1 and BTB domain-containing protein 1; May be involved in cell cycle regulation by chromatin remodeling. (531 aa)    
Predicted Functional Partners:
CUL3
Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...]
   
 
 0.808
RCBTB2
RCC1 and BTB domain containing protein 2.
  
 
0.698
CDADC1
Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
 
  
 0.641
NUDCD1
NudC domain containing 1.
   
 
 0.624
PHF11
PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression.
   
 
 0.624
NUDCD2
NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
   
   0.611
ZNF408
Zinc finger protein 408; May be involved in transcriptional regulation.
   
 
 0.605
SETDB2
Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
   
 
 0.600
OR6N1
Olfactory receptor 6N1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.570
MLNR
Motilin receptor; Receptor for motilin; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.541
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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