ANKEF1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKEF1	CCDC105	ENSP00000367644	ENSP00000292574	Ankyrin repeat and EF-hand domain containing 1.	Coiled-coil domain containing 105.	0.685
ANKEF1	CCDC40	ENSP00000367644	ENSP00000380679	Ankyrin repeat and EF-hand domain containing 1.	Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39. Belongs to the CCDC40 family.	0.683
ANKEF1	CFAP20	ENSP00000367644	ENSP00000262498	Ankyrin repeat and EF-hand domain containing 1.	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	0.754
ANKEF1	DYDC1	ENSP00000367644	ENSP00000361278	Ankyrin repeat and EF-hand domain containing 1.	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	0.701
ANKEF1	EFHC1	ENSP00000367644	ENSP00000360107	Ankyrin repeat and EF-hand domain containing 1.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.692
ANKEF1	PPP1R32	ENSP00000367644	ENSP00000344140	Ankyrin repeat and EF-hand domain containing 1.	Protein phosphatase 1 regulatory subunit 32.	0.737
ANKEF1	RSPH3	ENSP00000367644	ENSP00000252655	Ankyrin repeat and EF-hand domain containing 1.	Radial spoke head protein 3 homolog; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia. Belongs to the flagellar radial spoke RSP3 family.	0.684
ANKEF1	SPAG8	ENSP00000367644	ENSP00000340982	Ankyrin repeat and EF-hand domain containing 1.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.699
ANKEF1	TEPP	ENSP00000367644	ENSP00000290871	Ankyrin repeat and EF-hand domain containing 1.	Testis, prostate and placenta expressed.	0.683
ANKEF1	WDR64	ENSP00000367644	ENSP00000355510	Ankyrin repeat and EF-hand domain containing 1.	WD repeat domain 64.	0.689
CCDC105	ANKEF1	ENSP00000292574	ENSP00000367644	Coiled-coil domain containing 105.	Ankyrin repeat and EF-hand domain containing 1.	0.685
CCDC105	CCDC40	ENSP00000292574	ENSP00000380679	Coiled-coil domain containing 105.	Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39. Belongs to the CCDC40 family.	0.863
CCDC105	CFAP20	ENSP00000292574	ENSP00000262498	Coiled-coil domain containing 105.	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	0.906
CCDC105	DYDC1	ENSP00000292574	ENSP00000361278	Coiled-coil domain containing 105.	DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.	0.634
CCDC105	EFHC1	ENSP00000292574	ENSP00000360107	Coiled-coil domain containing 105.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.948
CCDC105	PPP1R32	ENSP00000292574	ENSP00000344140	Coiled-coil domain containing 105.	Protein phosphatase 1 regulatory subunit 32.	0.935
CCDC105	RSPH3	ENSP00000292574	ENSP00000252655	Coiled-coil domain containing 105.	Radial spoke head protein 3 homolog; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia. Belongs to the flagellar radial spoke RSP3 family.	0.724
CCDC105	SPAG8	ENSP00000292574	ENSP00000340982	Coiled-coil domain containing 105.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.960
CCDC105	TEPP	ENSP00000292574	ENSP00000290871	Coiled-coil domain containing 105.	Testis, prostate and placenta expressed.	0.952
CCDC105	WDR64	ENSP00000292574	ENSP00000355510	Coiled-coil domain containing 105.	WD repeat domain 64.	0.676