node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS4 | LUM | ENSP00000356975 | ENSP00000266718 | A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.452 |
ADAMTS4 | SRPX | ENSP00000356975 | ENSP00000367794 | A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.406 |
BRS3 | CCDC80 | ENSP00000359682 | ENSP00000206423 | Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | 0.917 |
BRS3 | SRPX | ENSP00000359682 | ENSP00000367794 | Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.842 |
CCDC80 | BRS3 | ENSP00000206423 | ENSP00000359682 | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.917 |
CCDC80 | LUM | ENSP00000206423 | ENSP00000266718 | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.443 |
CCDC80 | SRPX | ENSP00000206423 | ENSP00000367794 | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.499 |
CYBB | SRPX | ENSP00000367851 | ENSP00000367794 | Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.511 |
FAT4 | LUM | ENSP00000377862 | ENSP00000266718 | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.439 |
FAT4 | SRPX | ENSP00000377862 | ENSP00000367794 | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.441 |
FAT4 | TMEM17 | ENSP00000377862 | ENSP00000335094 | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the TMEM17 family. | 0.416 |
GPC3 | SRPX | ENSP00000377836 | ENSP00000367794 | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligand [...] | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.491 |
LUM | ADAMTS4 | ENSP00000266718 | ENSP00000356975 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. | 0.452 |
LUM | CCDC80 | ENSP00000266718 | ENSP00000206423 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | 0.443 |
LUM | FAT4 | ENSP00000266718 | ENSP00000377862 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). | 0.439 |
LUM | SRPX | ENSP00000266718 | ENSP00000367794 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | 0.610 |
SRPX | ADAMTS4 | ENSP00000367794 | ENSP00000356975 | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. | 0.406 |
SRPX | BRS3 | ENSP00000367794 | ENSP00000359682 | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.842 |
SRPX | CCDC80 | ENSP00000367794 | ENSP00000206423 | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | 0.499 |
SRPX | CYBB | ENSP00000367794 | ENSP00000367851 | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. | Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. | 0.511 |