node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP11C | FAM214B | ENSP00000332756 | ENSP00000367823 | Phospholipid-transporting ATPase IG; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for [...] | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.526 |
CEBPZOS | FAM214B | ENSP00000384331 | ENSP00000367823 | Protein CEBPZOS; CEBPZ opposite strand. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.585 |
DGKA | FAM214B | ENSP00000377703 | ENSP00000367823 | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.515 |
DNAJA3 | FAM214B | ENSP00000262375 | ENSP00000367823 | DnaJ homolog subfamily A member 3, mitochondrial; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.486 |
FAM214B | ATP11C | ENSP00000367823 | ENSP00000332756 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Phospholipid-transporting ATPase IG; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for [...] | 0.526 |
FAM214B | CEBPZOS | ENSP00000367823 | ENSP00000384331 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Protein CEBPZOS; CEBPZ opposite strand. | 0.585 |
FAM214B | DGKA | ENSP00000367823 | ENSP00000377703 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. | 0.515 |
FAM214B | DNAJA3 | ENSP00000367823 | ENSP00000262375 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | DnaJ homolog subfamily A member 3, mitochondrial; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. | 0.486 |
FAM214B | KIF20A | ENSP00000367823 | ENSP00000378356 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end- directed motility. | 0.619 |
FAM214B | RAPH1 | ENSP00000367823 | ENSP00000316543 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Ras-associated and pleckstrin homology domains-containing protein 1; Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. | 0.507 |
FAM214B | RHNO1 | ENSP00000367823 | ENSP00000479598 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. | 0.505 |
FAM214B | SCAPER | ENSP00000367823 | ENSP00000454973 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. | 0.507 |
FAM214B | TENT5A | ENSP00000367823 | ENSP00000318298 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase. | 0.508 |
FAM214B | ZNHIT1 | ENSP00000367823 | ENSP00000304593 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity ; Belongs to the ZNHIT1 family. | 0.500 |
KIF20A | FAM214B | ENSP00000378356 | ENSP00000367823 | Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end- directed motility. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.619 |
RAPH1 | FAM214B | ENSP00000316543 | ENSP00000367823 | Ras-associated and pleckstrin homology domains-containing protein 1; Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.507 |
RHNO1 | FAM214B | ENSP00000479598 | ENSP00000367823 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.505 |
RHNO1 | ZNHIT1 | ENSP00000479598 | ENSP00000304593 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity ; Belongs to the ZNHIT1 family. | 0.428 |
SCAPER | FAM214B | ENSP00000454973 | ENSP00000367823 | S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.507 |
TENT5A | FAM214B | ENSP00000318298 | ENSP00000367823 | Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase. | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family. | 0.508 |