| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM9A | MAJIN | ENSP00000440163 | ENSP00000301896 | Protein FAM9A; Family with sequence similarity 9 member A. | Membrane anchored junction protein. | 0.453 |
| FAM9A | MEIOC | ENSP00000440163 | ENSP00000386452 | Protein FAM9A; Family with sequence similarity 9 member A. | Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. | 0.494 |
| FAM9A | SYCE1L | ENSP00000440163 | ENSP00000367911 | Protein FAM9A; Family with sequence similarity 9 member A. | Synaptonemal complex central element protein 1-like; May be involved in meiosis. | 0.514 |
| FAM9A | TEX19 | ENSP00000440163 | ENSP00000331500 | Protein FAM9A; Family with sequence similarity 9 member A. | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...] | 0.452 |
| FAM9B | MAJIN | ENSP00000318716 | ENSP00000301896 | Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family. | Membrane anchored junction protein. | 0.436 |
| FAM9B | MEIOC | ENSP00000318716 | ENSP00000386452 | Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family. | Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. | 0.449 |
| FAM9B | SYCE1L | ENSP00000318716 | ENSP00000367911 | Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family. | Synaptonemal complex central element protein 1-like; May be involved in meiosis. | 0.548 |
| FAM9B | TEX19 | ENSP00000318716 | ENSP00000331500 | Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family. | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...] | 0.437 |
| FAM9C | MAJIN | ENSP00000334430 | ENSP00000301896 | Protein FAM9C; Family with sequence similarity 9 member C. | Membrane anchored junction protein. | 0.454 |
| FAM9C | MEIOC | ENSP00000334430 | ENSP00000386452 | Protein FAM9C; Family with sequence similarity 9 member C. | Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. | 0.507 |
| FAM9C | SYCE1L | ENSP00000334430 | ENSP00000367911 | Protein FAM9C; Family with sequence similarity 9 member C. | Synaptonemal complex central element protein 1-like; May be involved in meiosis. | 0.532 |
| FAM9C | TEX19 | ENSP00000334430 | ENSP00000331500 | Protein FAM9C; Family with sequence similarity 9 member C. | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...] | 0.495 |
| HORMAD2 | MAJIN | ENSP00000385055 | ENSP00000301896 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Membrane anchored junction protein. | 0.670 |
| HORMAD2 | MEIOC | ENSP00000385055 | ENSP00000386452 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. | 0.645 |
| HORMAD2 | SYCE1L | ENSP00000385055 | ENSP00000367911 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Synaptonemal complex central element protein 1-like; May be involved in meiosis. | 0.470 |
| HORMAD2 | SYCE2 | ENSP00000385055 | ENSP00000293695 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity). Belongs to the SYCE family. | 0.727 |
| HORMAD2 | TEX19 | ENSP00000385055 | ENSP00000331500 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...] | 0.432 |
| MAJIN | FAM9A | ENSP00000301896 | ENSP00000440163 | Membrane anchored junction protein. | Protein FAM9A; Family with sequence similarity 9 member A. | 0.453 |
| MAJIN | FAM9B | ENSP00000301896 | ENSP00000318716 | Membrane anchored junction protein. | Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family. | 0.436 |
| MAJIN | FAM9C | ENSP00000301896 | ENSP00000334430 | Membrane anchored junction protein. | Protein FAM9C; Family with sequence similarity 9 member C. | 0.454 |
