node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM18 | ATAD3C | ENSP00000265707 | ENSP00000368062 | Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.504 |
ATAD3C | ADAM18 | ENSP00000368062 | ENSP00000265707 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity); ADAM metallopeptidase domain containing | 0.504 |
ATAD3C | C8orf44 | ENSP00000368062 | ENSP00000428002 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.595 |
ATAD3C | CYB5RL | ENSP00000368062 | ENSP00000434343 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.514 |
ATAD3C | EPRS | ENSP00000368062 | ENSP00000355890 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript- selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase co [...] | 0.523 |
ATAD3C | GOLGA6L9 | ENSP00000368062 | ENSP00000481078 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Golgin subfamily A member 6-like protein 9; Golgin A6 family-like 9; Belongs to the GOLGA6 family | 0.557 |
ATAD3C | HSPD1 | ENSP00000368062 | ENSP00000373620 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Heat shock protein family d (hsp60) member 1; 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complex [...] | 0.518 |
ATAD3C | OXA1L | ENSP00000368062 | ENSP00000483491 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Mitochondrial inner membrane protein OXA1L; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria; Belongs to the OXA1/ALB3/YidC family | 0.586 |
ATAD3C | PHB | ENSP00000368062 | ENSP00000479488 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Prohibitin 1; Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging | 0.597 |
ATAD3C | PHB2 | ENSP00000368062 | ENSP00000441875 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.495 |
ATAD3C | POLG2 | ENSP00000368062 | ENSP00000442563 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA | 0.493 |
C8orf44 | ATAD3C | ENSP00000428002 | ENSP00000368062 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.595 |
C8orf44 | CYB5RL | ENSP00000428002 | ENSP00000434343 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.652 |
CYB5RL | ATAD3C | ENSP00000434343 | ENSP00000368062 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.514 |
CYB5RL | C8orf44 | ENSP00000434343 | ENSP00000428002 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.652 |
EPRS | ATAD3C | ENSP00000355890 | ENSP00000368062 | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript- selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase co [...] | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.523 |
EPRS | HSPD1 | ENSP00000355890 | ENSP00000373620 | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript- selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase co [...] | Heat shock protein family d (hsp60) member 1; 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complex [...] | 0.466 |
EPRS | PHB | ENSP00000355890 | ENSP00000479488 | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript- selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase co [...] | Prohibitin 1; Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging | 0.486 |
EPRS | POLG2 | ENSP00000355890 | ENSP00000442563 | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript- selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase co [...] | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA | 0.984 |
GOLGA6L9 | ATAD3C | ENSP00000481078 | ENSP00000368062 | Golgin subfamily A member 6-like protein 9; Golgin A6 family-like 9; Belongs to the GOLGA6 family | Atpase family aaa domain-containing protein 3c; ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family | 0.557 |