node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS9 | DHRS13 | ENSP00000418735 | ENSP00000368173 | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.561 |
ADAMTS9 | PRSS35 | ENSP00000418735 | ENSP00000358714 | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | Serine protease 35; Belongs to the peptidase S1 family. | 0.446 |
ANKRD39 | DHRS13 | ENSP00000377170 | ENSP00000368173 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.476 |
DHRS13 | ADAMTS9 | ENSP00000368173 | ENSP00000418735 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | 0.561 |
DHRS13 | ANKRD39 | ENSP00000368173 | ENSP00000377170 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | 0.476 |
DHRS13 | FAM131A | ENSP00000368173 | ENSP00000373360 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Protein FAM131A; Family with sequence similarity 131 member A. | 0.479 |
DHRS13 | FLOT2 | ENSP00000368173 | ENSP00000378368 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily. | 0.476 |
DHRS13 | GLIPR1L2 | ENSP00000368173 | ENSP00000448248 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | GLIPR1-like protein 2; GLIPR1 like 2; Belongs to the CRISP family. | 0.470 |
DHRS13 | KCNQ3 | ENSP00000368173 | ENSP00000373648 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | 0.485 |
DHRS13 | OXSM | ENSP00000368173 | ENSP00000280701 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.473 |
DHRS13 | PRSS35 | ENSP00000368173 | ENSP00000358714 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Serine protease 35; Belongs to the peptidase S1 family. | 0.564 |
DHRS13 | RGS17 | ENSP00000368173 | ENSP00000206262 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | 0.508 |
DHRS13 | SIGLEC15 | ENSP00000368173 | ENSP00000374125 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Sialic acid-binding Ig-like lectin 15; Binds sialylated glycoproteins. | 0.475 |
FAM131A | DHRS13 | ENSP00000373360 | ENSP00000368173 | Protein FAM131A; Family with sequence similarity 131 member A. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.479 |
FLOT2 | DHRS13 | ENSP00000378368 | ENSP00000368173 | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.476 |
GLIPR1L2 | DHRS13 | ENSP00000448248 | ENSP00000368173 | GLIPR1-like protein 2; GLIPR1 like 2; Belongs to the CRISP family. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.470 |
KCNQ3 | DHRS13 | ENSP00000373648 | ENSP00000368173 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.485 |
KCNQ3 | PRSS35 | ENSP00000373648 | ENSP00000358714 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | Serine protease 35; Belongs to the peptidase S1 family. | 0.416 |
KCNQ3 | RGS17 | ENSP00000373648 | ENSP00000206262 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | 0.425 |
OXSM | DHRS13 | ENSP00000280701 | ENSP00000368173 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.473 |