node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAH6 | MAGEB4 | ENSP00000374045 | ENSP00000368266 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Melanoma-associated antigen B4; MAGE family member B4. | 0.456 |
DNAH6 | TEX15 | ENSP00000374045 | ENSP00000493555 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Testis-expressed protein 15; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. Belongs to the TEX15 family. | 0.426 |
DNAH6 | TSGA10 | ENSP00000374045 | ENSP00000377123 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. | 0.423 |
DNAH6 | ZMYND15 | ENSP00000374045 | ENSP00000269289 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis. | 0.418 |
MAGEA1 | MAGEB4 | ENSP00000349085 | ENSP00000368266 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | Melanoma-associated antigen B4; MAGE family member B4. | 0.499 |
MAGEB4 | DNAH6 | ENSP00000368266 | ENSP00000374045 | Melanoma-associated antigen B4; MAGE family member B4. | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | 0.456 |
MAGEB4 | MAGEA1 | ENSP00000368266 | ENSP00000349085 | Melanoma-associated antigen B4; MAGE family member B4. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.499 |
MAGEB4 | MEGF8 | ENSP00000368266 | ENSP00000251268 | Melanoma-associated antigen B4; MAGE family member B4. | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | 0.431 |
MAGEB4 | NR0B1 | ENSP00000368266 | ENSP00000368253 | Melanoma-associated antigen B4; MAGE family member B4. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). | 0.481 |
MAGEB4 | ROCK1 | ENSP00000368266 | ENSP00000382697 | Melanoma-associated antigen B4; MAGE family member B4. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as [...] | 0.591 |
MAGEB4 | TEX11 | ENSP00000368266 | ENSP00000379226 | Melanoma-associated antigen B4; MAGE family member B4. | Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. | 0.505 |
MAGEB4 | TEX15 | ENSP00000368266 | ENSP00000493555 | Melanoma-associated antigen B4; MAGE family member B4. | Testis-expressed protein 15; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. Belongs to the TEX15 family. | 0.488 |
MAGEB4 | TSGA10 | ENSP00000368266 | ENSP00000377123 | Melanoma-associated antigen B4; MAGE family member B4. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. | 0.434 |
MAGEB4 | XAGE3 | ENSP00000368266 | ENSP00000303061 | Melanoma-associated antigen B4; MAGE family member B4. | X antigen family member 3. | 0.444 |
MAGEB4 | ZMYND15 | ENSP00000368266 | ENSP00000269289 | Melanoma-associated antigen B4; MAGE family member B4. | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis. | 0.475 |
MEGF8 | MAGEB4 | ENSP00000251268 | ENSP00000368266 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | Melanoma-associated antigen B4; MAGE family member B4. | 0.431 |
NR0B1 | MAGEB4 | ENSP00000368253 | ENSP00000368266 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). | Melanoma-associated antigen B4; MAGE family member B4. | 0.481 |
NR0B1 | TEX11 | ENSP00000368253 | ENSP00000379226 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). | Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. | 0.402 |
ROCK1 | MAGEB4 | ENSP00000382697 | ENSP00000368266 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as [...] | Melanoma-associated antigen B4; MAGE family member B4. | 0.591 |
TEX11 | MAGEB4 | ENSP00000379226 | ENSP00000368266 | Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. | Melanoma-associated antigen B4; MAGE family member B4. | 0.505 |