STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C11orf91Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. (193 aa)    
Predicted Functional Partners:
FBXO3
F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
      
 0.604
TCP11L1
T-complex protein 11-like protein 1; T-complex 11 like 1.
      
 0.507
OR13C5
Olfactory receptor 13C5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.507
CCDC73
Coiled-coil domain containing 73.
      
 0.447
KIAA1549L
UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family.
      
 0.446
C11orf74
Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.
      
 0.434
DEPDC7
DEP domain containing 7; Belongs to the DEPDC7 family.
      
 0.418
QSER1
Glutamine and serine rich 1.
      
 0.414
COMMD9
COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride- sensitive sodium channel (ENaC) subunits.
      
 0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.