node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFF2 | IL1RAPL1 | ENSP00000359489 | ENSP00000368278 | AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). ECO:0000250|UniProtKB:P59824, ; Belongs to the interleukin-1 receptor family. | 0.568 |
AFF2 | MAGEB10 | ENSP00000359489 | ENSP00000368304 | AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. | Melanoma-associated antigen B10; MAGE family member B10. | 0.495 |
IL1RAPL1 | AFF2 | ENSP00000368278 | ENSP00000359489 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). ECO:0000250|UniProtKB:P59824, ; Belongs to the interleukin-1 receptor family. | AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. | 0.568 |
IL1RAPL1 | MAGEB10 | ENSP00000368278 | ENSP00000368304 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). ECO:0000250|UniProtKB:P59824, ; Belongs to the interleukin-1 receptor family. | Melanoma-associated antigen B10; MAGE family member B10. | 0.515 |
KLF12 | MAGEB10 | ENSP00000366897 | ENSP00000368304 | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. | Melanoma-associated antigen B10; MAGE family member B10. | 0.473 |
MAGEB10 | AFF2 | ENSP00000368304 | ENSP00000359489 | Melanoma-associated antigen B10; MAGE family member B10. | AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. | 0.495 |
MAGEB10 | IL1RAPL1 | ENSP00000368304 | ENSP00000368278 | Melanoma-associated antigen B10; MAGE family member B10. | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). ECO:0000250|UniProtKB:P59824, ; Belongs to the interleukin-1 receptor family. | 0.515 |
MAGEB10 | KLF12 | ENSP00000368304 | ENSP00000366897 | Melanoma-associated antigen B10; MAGE family member B10. | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. | 0.473 |
MAGEB10 | MRFAP1L1 | ENSP00000368304 | ENSP00000318154 | Melanoma-associated antigen B10; MAGE family member B10. | Morf4 family associated protein 1 like 1. | 0.505 |
MAGEB10 | NEUROD2 | ENSP00000368304 | ENSP00000306754 | Melanoma-associated antigen B10; MAGE family member B10. | Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocor [...] | 0.465 |
MAGEB10 | NSMCE1 | ENSP00000368304 | ENSP00000355077 | Melanoma-associated antigen B10; MAGE family member B10. | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | 0.492 |
MAGEB10 | PAGE2B | ENSP00000368304 | ENSP00000364110 | Melanoma-associated antigen B10; MAGE family member B10. | PAGE family member 2B; Belongs to the GAGE family. | 0.477 |
MAGEB10 | PRSS55 | ENSP00000368304 | ENSP00000333003 | Melanoma-associated antigen B10; MAGE family member B10. | Serine protease 55; Probable serine protease. | 0.483 |
MAGEB10 | XAGE3 | ENSP00000368304 | ENSP00000303061 | Melanoma-associated antigen B10; MAGE family member B10. | X antigen family member 3. | 0.444 |
MAGEB10 | XAGE5 | ENSP00000368304 | ENSP00000342240 | Melanoma-associated antigen B10; MAGE family member B10. | X antigen family member 5; Belongs to the GAGE family. | 0.578 |
MRFAP1L1 | MAGEB10 | ENSP00000318154 | ENSP00000368304 | Morf4 family associated protein 1 like 1. | Melanoma-associated antigen B10; MAGE family member B10. | 0.505 |
NEUROD2 | MAGEB10 | ENSP00000306754 | ENSP00000368304 | Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocor [...] | Melanoma-associated antigen B10; MAGE family member B10. | 0.465 |
NSMCE1 | MAGEB10 | ENSP00000355077 | ENSP00000368304 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] | Melanoma-associated antigen B10; MAGE family member B10. | 0.492 |
PAGE2B | MAGEB10 | ENSP00000364110 | ENSP00000368304 | PAGE family member 2B; Belongs to the GAGE family. | Melanoma-associated antigen B10; MAGE family member B10. | 0.477 |
PRSS55 | MAGEB10 | ENSP00000333003 | ENSP00000368304 | Serine protease 55; Probable serine protease. | Melanoma-associated antigen B10; MAGE family member B10. | 0.483 |