KCTD4 protein (human) - STRING interaction network

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KCTD4

BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4. (259 aa)

Predicted Functional Partners:

KCTD20

0.703

BTBD10

0.634

CBY2

0.572

GTF2F2

0.514

KCTD18

0.488

KCTD3

0.471

CEP97

0.464

KCTD2

0.462

KCTD14

0.441

KCTD10

0.432

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD10	KCTD10	ENSP00000431186	ENSP00000228495	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	0.575
BTBD10	KCTD14	ENSP00000431186	ENSP00000316482	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14.	0.631
BTBD10	KCTD18	ENSP00000431186	ENSP00000352941	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18.	0.709
BTBD10	KCTD2	ENSP00000431186	ENSP00000312814	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2.	0.674
BTBD10	KCTD3	ENSP00000431186	ENSP00000259154	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family.	0.570
BTBD10	KCTD4	ENSP00000431186	ENSP00000368402	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4.	0.634
CBY2	GTF2F2	ENSP00000309189	ENSP00000340823	Chibby family member 2.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.539
CBY2	KCTD4	ENSP00000309189	ENSP00000368402	Chibby family member 2.	BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4.	0.572
CEP97	KCTD10	ENSP00000342510	ENSP00000228495	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	0.658
CEP97	KCTD18	ENSP00000342510	ENSP00000352941	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18.	0.489
CEP97	KCTD3	ENSP00000342510	ENSP00000259154	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics; Belongs to the KCTD3 family.	0.491
CEP97	KCTD4	ENSP00000342510	ENSP00000368402	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4.	0.464
GTF2F2	CBY2	ENSP00000340823	ENSP00000309189	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	Chibby family member 2.	0.539
GTF2F2	KCTD4	ENSP00000340823	ENSP00000368402	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4.	0.514
KCTD10	BTBD10	ENSP00000228495	ENSP00000431186	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	0.575
KCTD10	CEP97	ENSP00000228495	ENSP00000342510	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	0.658
KCTD10	KCTD14	ENSP00000228495	ENSP00000316482	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14.	0.497
KCTD10	KCTD18	ENSP00000228495	ENSP00000352941	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18.	0.517
KCTD10	KCTD2	ENSP00000228495	ENSP00000312814	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2.	0.521
KCTD10	KCTD20	ENSP00000228495	ENSP00000362836	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members.	0.647