C4orf46 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	C4orf46	ENSP00000220592	ENSP00000368503	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	0.457
AGO2	CDR2L	ENSP00000220592	ENSP00000336587	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Cerebellar degeneration related protein 2 like.	0.462
AGO2	NDUFAF4	ENSP00000220592	ENSP00000358272	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	0.470
BHLHA9	C4orf46	ENSP00000375248	ENSP00000368503	Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	0.538
BHLHA9	RD3L	ENSP00000375248	ENSP00000455434	Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.	Protein RD3-like; Retinal degeneration 3 like.	0.550
C4orf46	AGO2	ENSP00000368503	ENSP00000220592	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.457
C4orf46	BHLHA9	ENSP00000368503	ENSP00000375248	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.	0.538
C4orf46	CDR2	ENSP00000368503	ENSP00000268383	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	Cerebellar degeneration related protein 2.	0.969
C4orf46	CDR2L	ENSP00000368503	ENSP00000336587	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	Cerebellar degeneration related protein 2 like.	0.918
C4orf46	NDUFAF4	ENSP00000368503	ENSP00000358272	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	0.416
C4orf46	OSBPL3	ENSP00000368503	ENSP00000315410	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...]	0.400
C4orf46	RD3L	ENSP00000368503	ENSP00000455434	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	Protein RD3-like; Retinal degeneration 3 like.	0.578
C4orf46	SRPK2	ENSP00000368503	ENSP00000377262	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	SRSF protein kinase 2 C-terminal; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates [...]	0.467
CDR2	C4orf46	ENSP00000268383	ENSP00000368503	Cerebellar degeneration related protein 2.	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	0.969
CDR2	CDR2L	ENSP00000268383	ENSP00000336587	Cerebellar degeneration related protein 2.	Cerebellar degeneration related protein 2 like.	0.999
CDR2L	AGO2	ENSP00000336587	ENSP00000220592	Cerebellar degeneration related protein 2 like.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.462
CDR2L	C4orf46	ENSP00000336587	ENSP00000368503	Cerebellar degeneration related protein 2 like.	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	0.918
CDR2L	CDR2	ENSP00000336587	ENSP00000268383	Cerebellar degeneration related protein 2 like.	Cerebellar degeneration related protein 2.	0.999
NDUFAF4	AGO2	ENSP00000358272	ENSP00000220592	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.470
NDUFAF4	C4orf46	ENSP00000358272	ENSP00000368503	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.	0.416