node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GFOD1 | GFOD2 | ENSP00000368589 | ENSP00000268797 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.784 |
GFOD1 | KARS1 | ENSP00000368589 | ENSP00000325448 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | 0.625 |
GFOD1 | KRTAP20-4 | ENSP00000368589 | ENSP00000372278 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Putative keratin-associated protein 20-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 20 family. | 0.724 |
GFOD1 | NKIRAS2 | ENSP00000368589 | ENSP00000303580 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. | 0.784 |
GFOD1 | RALGAPA1 | ENSP00000368589 | ENSP00000490119 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Ral GTPase-activating protein subunit alpha-1; Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. | 0.646 |
GFOD1 | RALGAPA2 | ENSP00000368589 | ENSP00000202677 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Ral GTPase-activating protein subunit alpha-2; Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. | 0.727 |
GFOD1 | RALGAPB | ENSP00000368589 | ENSP00000262879 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. | 0.581 |
GFOD1 | RGN | ENSP00000368589 | ENSP00000380365 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)- dependent cellular processes and enzyme activities (By similarity). | 0.699 |
GFOD1 | RHOQ | ENSP00000368589 | ENSP00000238738 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Rho-related GTP-binding protein RhoQ; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. | 0.552 |
GFOD1 | TGDS | ENSP00000368589 | ENSP00000261296 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | TDP-glucose 4,6-dehydratase. | 0.724 |
GFOD2 | GFOD1 | ENSP00000268797 | ENSP00000368589 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | 0.784 |
GFOD2 | KARS1 | ENSP00000268797 | ENSP00000325448 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | 0.625 |
GFOD2 | NKIRAS2 | ENSP00000268797 | ENSP00000303580 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. | 0.797 |
GFOD2 | RGN | ENSP00000268797 | ENSP00000380365 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)- dependent cellular processes and enzyme activities (By similarity). | 0.699 |
GFOD2 | TGDS | ENSP00000268797 | ENSP00000261296 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | TDP-glucose 4,6-dehydratase. | 0.739 |
KARS1 | GFOD1 | ENSP00000325448 | ENSP00000368589 | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | 0.625 |
KARS1 | GFOD2 | ENSP00000325448 | ENSP00000268797 | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.625 |
KRTAP20-4 | GFOD1 | ENSP00000372278 | ENSP00000368589 | Putative keratin-associated protein 20-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 20 family. | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | 0.724 |
NKIRAS2 | GFOD1 | ENSP00000303580 | ENSP00000368589 | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | 0.784 |
NKIRAS2 | GFOD2 | ENSP00000303580 | ENSP00000268797 | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.797 |