TMEM170B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL5	TMEM170B	ENSP00000472681	ENSP00000368737	Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.484
C14orf178	TMEM170B	ENSP00000348145	ENSP00000368737	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.550
ERP27	TMEM170B	ENSP00000266397	ENSP00000368737	Endoplasmic reticulum resident protein 27; Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.418
MFSD13A	TMEM168	ENSP00000238936	ENSP00000323068	Transmembrane protein 180; Major facilitator superfamily domain containing 13A.	Transmembrane protein 168; Belongs to the TMEM168 family.	0.538
MFSD13A	TMEM170B	ENSP00000238936	ENSP00000368737	Transmembrane protein 180; Major facilitator superfamily domain containing 13A.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.459
MFSD13A	TMEM45B	ENSP00000238936	ENSP00000281441	Transmembrane protein 180; Major facilitator superfamily domain containing 13A.	Transmembrane protein 45B.	0.493
MFSD13A	TMEM98	ENSP00000238936	ENSP00000463245	Transmembrane protein 180; Major facilitator superfamily domain containing 13A.	Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).	0.420
SCAF4	TMEM170B	ENSP00000286835	ENSP00000368737	SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...]	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.461
TMEM158	TMEM168	ENSP00000422431	ENSP00000323068	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 168; Belongs to the TMEM168 family.	0.470
TMEM158	TMEM170B	ENSP00000422431	ENSP00000368737	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.410
TMEM158	TMEM45B	ENSP00000422431	ENSP00000281441	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 45B.	0.427
TMEM158	TMEM98	ENSP00000422431	ENSP00000463245	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).	0.494
TMEM168	MFSD13A	ENSP00000323068	ENSP00000238936	Transmembrane protein 168; Belongs to the TMEM168 family.	Transmembrane protein 180; Major facilitator superfamily domain containing 13A.	0.538
TMEM168	TMEM158	ENSP00000323068	ENSP00000422431	Transmembrane protein 168; Belongs to the TMEM168 family.	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	0.470
TMEM168	TMEM170B	ENSP00000323068	ENSP00000368737	Transmembrane protein 168; Belongs to the TMEM168 family.	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	0.524
TMEM168	TMEM45B	ENSP00000323068	ENSP00000281441	Transmembrane protein 168; Belongs to the TMEM168 family.	Transmembrane protein 45B.	0.439
TMEM168	TMEM98	ENSP00000323068	ENSP00000463245	Transmembrane protein 168; Belongs to the TMEM168 family.	Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).	0.427
TMEM170B	ASCL5	ENSP00000368737	ENSP00000472681	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5.	0.484
TMEM170B	C14orf178	ENSP00000368737	ENSP00000348145	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.	0.550
TMEM170B	ERP27	ENSP00000368737	ENSP00000266397	Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.	Endoplasmic reticulum resident protein 27; Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response.	0.418