node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAIAP3 | KCNN1 | ENSP00000324510 | ENSP00000476519 | BAI1-associated protein 3; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans- Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters [...] | Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity); Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily. | 0.446 |
BAIAP3 | KLHL34 | ENSP00000324510 | ENSP00000368813 | BAI1-associated protein 3; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans- Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters [...] | Kelch-like protein 34; Kelch like family member 34. | 0.482 |
DAB2IP | KLHL34 | ENSP00000259371 | ENSP00000368813 | Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor- mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...] | Kelch-like protein 34; Kelch like family member 34. | 0.443 |
FABP3 | KLHL34 | ENSP00000362817 | ENSP00000368813 | Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Kelch-like protein 34; Kelch like family member 34. | 0.430 |
KCNN1 | BAIAP3 | ENSP00000476519 | ENSP00000324510 | Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity); Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily. | BAI1-associated protein 3; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans- Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters [...] | 0.446 |
KCNN1 | KLHL34 | ENSP00000476519 | ENSP00000368813 | Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity); Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily. | Kelch-like protein 34; Kelch like family member 34. | 0.467 |
KLHL34 | BAIAP3 | ENSP00000368813 | ENSP00000324510 | Kelch-like protein 34; Kelch like family member 34. | BAI1-associated protein 3; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans- Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters [...] | 0.482 |
KLHL34 | DAB2IP | ENSP00000368813 | ENSP00000259371 | Kelch-like protein 34; Kelch like family member 34. | Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor- mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...] | 0.443 |
KLHL34 | FABP3 | ENSP00000368813 | ENSP00000362817 | Kelch-like protein 34; Kelch like family member 34. | Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.430 |
KLHL34 | KCNN1 | ENSP00000368813 | ENSP00000476519 | Kelch-like protein 34; Kelch like family member 34. | Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity); Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily. | 0.467 |
KLHL34 | LSMEM2 | ENSP00000368813 | ENSP00000315081 | Kelch-like protein 34; Kelch like family member 34. | Leucine rich single-pass membrane protein 2. | 0.495 |
LSMEM2 | KLHL34 | ENSP00000315081 | ENSP00000368813 | Leucine rich single-pass membrane protein 2. | Kelch-like protein 34; Kelch like family member 34. | 0.495 |