node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | EBNA1BP2 | ENSP00000338862 | ENSP00000407323 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.999 |
BRIX1 | GNL2 | ENSP00000338862 | ENSP00000362153 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels. | 0.943 |
BRIX1 | GTPBP4 | ENSP00000338862 | ENSP00000354040 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | 0.998 |
BRIX1 | MAK16 | ENSP00000338862 | ENSP00000353246 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | MAK16 homolog. | 0.997 |
BRIX1 | MRTO4 | ENSP00000338862 | ENSP00000364320 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.997 |
BRIX1 | NIP7 | ENSP00000338862 | ENSP00000254940 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. | 0.999 |
BRIX1 | PAK1IP1 | ENSP00000338862 | ENSP00000368887 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | 0.898 |
BRIX1 | RPF2 | ENSP00000338862 | ENSP00000402338 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.993 |
BRIX1 | RRP15 | ENSP00000338862 | ENSP00000355899 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | RRP15-like protein; Ribosomal RNA processing 15 homolog. | 0.984 |
BRIX1 | RSL24D1 | ENSP00000338862 | ENSP00000260443 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family. | 0.995 |
EBNA1BP2 | BRIX1 | ENSP00000407323 | ENSP00000338862 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.999 |
EBNA1BP2 | GNL2 | ENSP00000407323 | ENSP00000362153 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels. | 0.972 |
EBNA1BP2 | GTPBP4 | ENSP00000407323 | ENSP00000354040 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | 0.997 |
EBNA1BP2 | MAK16 | ENSP00000407323 | ENSP00000353246 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | MAK16 homolog. | 0.999 |
EBNA1BP2 | MRTO4 | ENSP00000407323 | ENSP00000364320 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.998 |
EBNA1BP2 | NIP7 | ENSP00000407323 | ENSP00000254940 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. | 0.999 |
EBNA1BP2 | PAK1IP1 | ENSP00000407323 | ENSP00000368887 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | 0.915 |
EBNA1BP2 | RPF2 | ENSP00000407323 | ENSP00000402338 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.999 |
EBNA1BP2 | RRP15 | ENSP00000407323 | ENSP00000355899 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | RRP15-like protein; Ribosomal RNA processing 15 homolog. | 0.977 |
EBNA1BP2 | RSL24D1 | ENSP00000407323 | ENSP00000260443 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family. | 0.993 |