node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC112 | CCDC14 | ENSP00000368931 | ENSP00000420180 | Coiled-coil domain containing 112. | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | 0.496 |
CCDC112 | ESYT1 | ENSP00000368931 | ENSP00000267113 | Coiled-coil domain containing 112. | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family. | 0.774 |
CCDC112 | KIAA0753 | ENSP00000368931 | ENSP00000355250 | Coiled-coil domain containing 112. | Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. | 0.438 |
CCDC112 | LTBR | ENSP00000368931 | ENSP00000228918 | Coiled-coil domain containing 112. | Tumor necrosis factor receptor superfamily member 3; Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. | 0.441 |
CCDC112 | MCOLN3 | ENSP00000368931 | ENSP00000359621 | Coiled-coil domain containing 112. | Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle gro [...] | 0.505 |
CCDC112 | NEXMIF | ENSP00000368931 | ENSP00000055682 | Coiled-coil domain containing 112. | Neurite extension and migration factor; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). | 0.444 |
CCDC112 | ODF2L | ENSP00000368931 | ENSP00000359600 | Coiled-coil domain containing 112. | Protein BCAP; Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis; Belongs to the ODF2 family. | 0.443 |
CCDC112 | PGGT1B | ENSP00000368931 | ENSP00000404676 | Coiled-coil domain containing 112. | Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. | 0.720 |
CCDC112 | TEX29 | ENSP00000368931 | ENSP00000283547 | Coiled-coil domain containing 112. | Testis-expressed protein 29; Testis expressed 29. | 0.669 |
CCDC112 | TEX9 | ENSP00000368931 | ENSP00000342169 | Coiled-coil domain containing 112. | Testis-expressed protein 9; Testis expressed 9. | 0.869 |
CCDC14 | CCDC112 | ENSP00000420180 | ENSP00000368931 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Coiled-coil domain containing 112. | 0.496 |
CCDC14 | KIAA0753 | ENSP00000420180 | ENSP00000355250 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. | 0.922 |
CCDC14 | ODF2L | ENSP00000420180 | ENSP00000359600 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Protein BCAP; Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis; Belongs to the ODF2 family. | 0.643 |
CCDC14 | TEX9 | ENSP00000420180 | ENSP00000342169 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Testis-expressed protein 9; Testis expressed 9. | 0.692 |
ESYT1 | CCDC112 | ENSP00000267113 | ENSP00000368931 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family. | Coiled-coil domain containing 112. | 0.774 |
KIAA0753 | CCDC112 | ENSP00000355250 | ENSP00000368931 | Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. | Coiled-coil domain containing 112. | 0.438 |
KIAA0753 | CCDC14 | ENSP00000355250 | ENSP00000420180 | Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | 0.922 |
KIAA0753 | TEX9 | ENSP00000355250 | ENSP00000342169 | Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. | Testis-expressed protein 9; Testis expressed 9. | 0.436 |
LTBR | CCDC112 | ENSP00000228918 | ENSP00000368931 | Tumor necrosis factor receptor superfamily member 3; Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. | Coiled-coil domain containing 112. | 0.441 |
MCOLN3 | CCDC112 | ENSP00000359621 | ENSP00000368931 | Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle gro [...] | Coiled-coil domain containing 112. | 0.505 |