node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF1AD | NOB1 | ENSP00000434056 | ENSP00000268802 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | 0.873 |
EIF1AD | PNO1 | ENSP00000434056 | ENSP00000263657 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. | 0.471 |
EIF1AD | RIOK1 | ENSP00000434056 | ENSP00000369162 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic associa [...] | 0.977 |
EIF1AD | RIOK2 | ENSP00000434056 | ENSP00000283109 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. | 0.410 |
EIF1AD | RPS14 | ENSP00000434056 | ENSP00000385958 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Ribosomal protein S14. | 0.801 |
EIF1AD | RPS2 | ENSP00000434056 | ENSP00000341885 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | Ribosomal protein S2. | 0.842 |
EIF1AD | RPS7 | ENSP00000434056 | ENSP00000495273 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | 40S ribosomal protein S7; Required for rRNA maturation. | 0.801 |
LTV1 | NOB1 | ENSP00000356548 | ENSP00000268802 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | 0.999 |
LTV1 | PNO1 | ENSP00000356548 | ENSP00000263657 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. | 0.998 |
LTV1 | RIOK1 | ENSP00000356548 | ENSP00000369162 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic associa [...] | 0.999 |
LTV1 | RIOK2 | ENSP00000356548 | ENSP00000283109 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. | 0.999 |
LTV1 | RPS14 | ENSP00000356548 | ENSP00000385958 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | Ribosomal protein S14. | 0.996 |
LTV1 | RPS2 | ENSP00000356548 | ENSP00000341885 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | Ribosomal protein S2. | 0.999 |
LTV1 | RPS7 | ENSP00000356548 | ENSP00000495273 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | 40S ribosomal protein S7; Required for rRNA maturation. | 0.993 |
NOB1 | EIF1AD | ENSP00000268802 | ENSP00000434056 | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation. | 0.873 |
NOB1 | LTV1 | ENSP00000268802 | ENSP00000356548 | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | Protein LTV1 homolog; LTV1 ribosome biogenesis factor. | 0.999 |
NOB1 | PNO1 | ENSP00000268802 | ENSP00000263657 | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. | 0.999 |
NOB1 | RIOK1 | ENSP00000268802 | ENSP00000369162 | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic associa [...] | 0.997 |
NOB1 | RIOK2 | ENSP00000268802 | ENSP00000283109 | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. | 0.999 |
NOB1 | RPS14 | ENSP00000268802 | ENSP00000385958 | RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); Belongs to the NOB1 family. | Ribosomal protein S14. | 0.995 |