node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APMAP | EQTN | ENSP00000217456 | ENSP00000369371 | Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family. | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | 0.485 |
APMAP | EXOSC10 | ENSP00000217456 | ENSP00000366135 | Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family. | Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | 0.868 |
EQTN | APMAP | ENSP00000369371 | ENSP00000217456 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family. | 0.485 |
EQTN | EXOSC10 | ENSP00000369371 | ENSP00000366135 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | 0.435 |
EQTN | FAM170B | ENSP00000369371 | ENSP00000308292 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.496 |
EQTN | IFNK | ENSP00000369371 | ENSP00000276943 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Interferon kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. | 0.471 |
EQTN | IZUMO1 | ENSP00000369371 | ENSP00000327786 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. | 0.462 |
EQTN | MOB3B | ENSP00000369371 | ENSP00000262244 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | MOB kinase activator 3B; Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | 0.554 |
EQTN | PAN3 | ENSP00000369371 | ENSP00000370345 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | 0.574 |
EQTN | PCNA | ENSP00000369371 | ENSP00000368458 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.658 |
EQTN | SPAM1 | ENSP00000369371 | ENSP00000345849 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid; Belongs to the glycosyl hydrolase 56 family. | 0.454 |
EQTN | TEX101 | ENSP00000369371 | ENSP00000472308 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). | 0.464 |
EXOSC10 | APMAP | ENSP00000366135 | ENSP00000217456 | Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family. | 0.868 |
EXOSC10 | EQTN | ENSP00000366135 | ENSP00000369371 | Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | 0.435 |
FAM170B | EQTN | ENSP00000308292 | ENSP00000369371 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | 0.496 |
IFNK | EQTN | ENSP00000276943 | ENSP00000369371 | Interferon kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | 0.471 |
IFNK | MOB3B | ENSP00000276943 | ENSP00000262244 | Interferon kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. | MOB kinase activator 3B; Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | 0.646 |
IZUMO1 | EQTN | ENSP00000327786 | ENSP00000369371 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | 0.462 |
MOB3B | EQTN | ENSP00000262244 | ENSP00000369371 | MOB kinase activator 3B; Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. | 0.554 |
MOB3B | IFNK | ENSP00000262244 | ENSP00000276943 | MOB kinase activator 3B; Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | Interferon kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. | 0.646 |