STRINGSTRING
IFNA16 protein (human) - STRING interaction network
"IFNA16" - Interferon, alpha 16 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFNA16Interferon, alpha 16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)    
Predicted Functional Partners:
IFNA14
Interferon, alpha 14; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.945
IFNA10
Interferon, alpha 10; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.945
IFNA8
Interferon, alpha 8; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.943
IFNA7
Interferon, alpha 7; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.936
IFNA17
Interferon, alpha 17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.926
IFNB1
Interferon, beta 1, fibroblast; Has antiviral, antibacterial and anticancer activities (187 aa)
     
 
0.919
IFNA21
Interferon, alpha 21; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.919
IFNA5
Interferon, alpha 5; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase (189 aa)
     
 
0.919
IFNAR1
Interferon (alpha, beta and omega) receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed-2153461, PubMed-7665574, PubMed-10049744, PubMed-14532120, PubMed-15337770, PubMed-21854986). Functions in general as heterodimer with IFNAR2 (PubMed-7665574, PubMed-10049744, PubMed-21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (PubMed-7665574, PubMed-21854986 [...] (557 aa)
         
  0.908
STAT2
Signal transducer and activator of transcription 2, 113kDa; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, whi [...] (851 aa)
         
  0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (7%) [HD]