FAM50B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM50A	FAM50B	ENSP00000377225	ENSP00000369627	Protein FAM50A; May be a DNA-binding protein or transcriptional factor.	Protein FAM50B; Family with sequence similarity 50 member B.	0.999
FAM50A	RPP25	ENSP00000377225	ENSP00000317691	Protein FAM50A; May be a DNA-binding protein or transcriptional factor.	Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.523
FAM50A	RPP25L	ENSP00000377225	ENSP00000297613	Protein FAM50A; May be a DNA-binding protein or transcriptional factor.	Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP.	0.559
FAM50B	FAM50A	ENSP00000369627	ENSP00000377225	Protein FAM50B; Family with sequence similarity 50 member B.	Protein FAM50A; May be a DNA-binding protein or transcriptional factor.	0.999
FAM50B	KPNA3	ENSP00000369627	ENSP00000261667	Protein FAM50B; Family with sequence similarity 50 member B.	Importin subunit alpha-4; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...]	0.654
FAM50B	LDOC1	ENSP00000369627	ENSP00000359557	Protein FAM50B; Family with sequence similarity 50 member B.	Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family.	0.638
FAM50B	MCTS2P	ENSP00000369627	ENSP00000496921	Protein FAM50B; Family with sequence similarity 50 member B.	Malignant T-cell-amplified sequence; MCTS family member 2, pseudogene.	0.547
FAM50B	NAP1L5	ENSP00000369627	ENSP00000320488	Protein FAM50B; Family with sequence similarity 50 member B.	Nucleosome assembly protein 1 like 5.	0.535
FAM50B	RPP25	ENSP00000369627	ENSP00000317691	Protein FAM50B; Family with sequence similarity 50 member B.	Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.514
FAM50B	RPP25L	ENSP00000369627	ENSP00000297613	Protein FAM50B; Family with sequence similarity 50 member B.	Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP.	0.517
FAM50B	TMPO	ENSP00000369627	ENSP00000266732	Protein FAM50B; Family with sequence similarity 50 member B.	Lamina-associated polypeptide 2, isoform alpha; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.	0.538
FAM50B	WDR20	ENSP00000369627	ENSP00000395793	Protein FAM50B; Family with sequence similarity 50 member B.	WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme.	0.557
FAM50B	ZDBF2	ENSP00000369627	ENSP00000497308	Protein FAM50B; Family with sequence similarity 50 member B.	DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2.	0.570
KPNA3	FAM50B	ENSP00000261667	ENSP00000369627	Importin subunit alpha-4; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...]	Protein FAM50B; Family with sequence similarity 50 member B.	0.654
LDOC1	FAM50B	ENSP00000359557	ENSP00000369627	Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family.	Protein FAM50B; Family with sequence similarity 50 member B.	0.638
MCTS2P	FAM50B	ENSP00000496921	ENSP00000369627	Malignant T-cell-amplified sequence; MCTS family member 2, pseudogene.	Protein FAM50B; Family with sequence similarity 50 member B.	0.547
MCTS2P	NAP1L5	ENSP00000496921	ENSP00000320488	Malignant T-cell-amplified sequence; MCTS family member 2, pseudogene.	Nucleosome assembly protein 1 like 5.	0.701
MCTS2P	WDR20	ENSP00000496921	ENSP00000395793	Malignant T-cell-amplified sequence; MCTS family member 2, pseudogene.	WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme.	0.536
MCTS2P	ZDBF2	ENSP00000496921	ENSP00000497308	Malignant T-cell-amplified sequence; MCTS family member 2, pseudogene.	DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2.	0.570
NAP1L5	FAM50B	ENSP00000320488	ENSP00000369627	Nucleosome assembly protein 1 like 5.	Protein FAM50B; Family with sequence similarity 50 member B.	0.535