node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLP2 | LHFPL2 | ENSP00000497691 | ENSP00000369702 | Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.491 |
APLP2 | PCDH7 | ENSP00000497691 | ENSP00000441802 | Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). | Protocadherin-7; Protocadherin 7. | 0.407 |
DUSP3 | LHFPL2 | ENSP00000226004 | ENSP00000369702 | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.450 |
HMGA2 | LHFPL2 | ENSP00000437621 | ENSP00000369702 | High mobility group AT-hook 2. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.463 |
LHFPL2 | APLP2 | ENSP00000369702 | ENSP00000497691 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). | 0.491 |
LHFPL2 | DUSP3 | ENSP00000369702 | ENSP00000226004 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. | 0.450 |
LHFPL2 | HMGA2 | ENSP00000369702 | ENSP00000437621 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | High mobility group AT-hook 2. | 0.463 |
LHFPL2 | OCIAD2 | ENSP00000369702 | ENSP00000423014 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | OCIA domain containing 2. | 0.456 |
LHFPL2 | PCDH7 | ENSP00000369702 | ENSP00000441802 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Protocadherin-7; Protocadherin 7. | 0.446 |
LHFPL2 | RASSF2 | ENSP00000369702 | ENSP00000368710 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. | 0.446 |
LHFPL2 | RNF182 | ENSP00000369702 | ENSP00000420465 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR- triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.476 |
LHFPL2 | TBC1D30 | ENSP00000369702 | ENSP00000440207 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. | 0.476 |
LHFPL2 | TMEM51 | ENSP00000369702 | ENSP00000365176 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Transmembrane protein 51. | 0.484 |
LHFPL2 | TMEM86A | ENSP00000369702 | ENSP00000280734 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A. | 0.467 |
OCIAD2 | LHFPL2 | ENSP00000423014 | ENSP00000369702 | OCIA domain containing 2. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.456 |
OCIAD2 | RNF182 | ENSP00000423014 | ENSP00000420465 | OCIA domain containing 2. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR- triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.469 |
OCIAD2 | TBC1D30 | ENSP00000423014 | ENSP00000440207 | OCIA domain containing 2. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. | 0.470 |
PCDH7 | APLP2 | ENSP00000441802 | ENSP00000497691 | Protocadherin-7; Protocadherin 7. | Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). | 0.407 |
PCDH7 | LHFPL2 | ENSP00000441802 | ENSP00000369702 | Protocadherin-7; Protocadherin 7. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.446 |
RASSF2 | LHFPL2 | ENSP00000368710 | ENSP00000369702 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.446 |