node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP10 | ARHGAP26 | ENSP00000336923 | ENSP00000274498 | Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). | Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42. | 0.820 |
ARHGAP10 | C2CD2 | ENSP00000336923 | ENSP00000369853 | Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). | C2 calcium dependent domain containing 2. | 0.807 |
ARHGAP26 | ARHGAP10 | ENSP00000274498 | ENSP00000336923 | Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42. | Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). | 0.820 |
ARHGAP26 | C2CD2 | ENSP00000274498 | ENSP00000369853 | Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42. | C2 calcium dependent domain containing 2. | 0.724 |
C2CD2 | ARHGAP10 | ENSP00000369853 | ENSP00000336923 | C2 calcium dependent domain containing 2. | Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). | 0.807 |
C2CD2 | ARHGAP26 | ENSP00000369853 | ENSP00000274498 | C2 calcium dependent domain containing 2. | Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42. | 0.724 |
C2CD2 | DYNC1LI2 | ENSP00000369853 | ENSP00000258198 | C2 calcium dependent domain containing 2. | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes; Belongs to the dynein light intermediate chain family. | 0.528 |
C2CD2 | ENDOD1 | ENSP00000369853 | ENSP00000278505 | C2 calcium dependent domain containing 2. | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase; Belongs to the DNA/RNA non-specific endonuclease family. | 0.492 |
C2CD2 | PRDM15 | ENSP00000369853 | ENSP00000269844 | C2 calcium dependent domain containing 2. | PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] | 0.496 |
C2CD2 | SEC14L1 | ENSP00000369853 | ENSP00000376268 | C2 calcium dependent domain containing 2. | SEC14-like protein 1; May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters. | 0.483 |
C2CD2 | TM2D1 | ENSP00000369853 | ENSP00000475700 | C2 calcium dependent domain containing 2. | TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. | 0.508 |
C2CD2 | TMEM158 | ENSP00000369853 | ENSP00000422431 | C2 calcium dependent domain containing 2. | Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. | 0.469 |
C2CD2 | ZBTB21 | ENSP00000369853 | ENSP00000308759 | C2 calcium dependent domain containing 2. | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor. | 0.670 |
C2CD2 | ZNF805 | ENSP00000369853 | ENSP00000412999 | C2 calcium dependent domain containing 2. | Zinc finger protein 805; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.505 |
DYNC1LI2 | C2CD2 | ENSP00000258198 | ENSP00000369853 | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes; Belongs to the dynein light intermediate chain family. | C2 calcium dependent domain containing 2. | 0.528 |
ENDOD1 | C2CD2 | ENSP00000278505 | ENSP00000369853 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase; Belongs to the DNA/RNA non-specific endonuclease family. | C2 calcium dependent domain containing 2. | 0.492 |
ENDOD1 | TM2D1 | ENSP00000278505 | ENSP00000475700 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase; Belongs to the DNA/RNA non-specific endonuclease family. | TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. | 0.475 |
PRDM15 | C2CD2 | ENSP00000269844 | ENSP00000369853 | PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] | C2 calcium dependent domain containing 2. | 0.496 |
PRDM15 | ZBTB21 | ENSP00000269844 | ENSP00000308759 | PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor. | 0.409 |
SEC14L1 | C2CD2 | ENSP00000376268 | ENSP00000369853 | SEC14-like protein 1; May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters. | C2 calcium dependent domain containing 2. | 0.483 |