node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSD | ARSI | ENSP00000370546 | ENSP00000333395 | Arylsulfatase D. | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | 0.650 |
ARSD | ARSJ | ENSP00000370546 | ENSP00000320219 | Arylsulfatase D. | Arylsulfatase family member J. | 0.638 |
ARSD | ARSK | ENSP00000370546 | ENSP00000369346 | Arylsulfatase D. | Arylsulfatase family member K. | 0.672 |
ARSD | CD99 | ENSP00000370546 | ENSP00000370588 | Arylsulfatase D. | CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). | 0.618 |
ARSD | GET3 | ENSP00000370546 | ENSP00000466379 | Arylsulfatase D. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.669 |
ARSD | MED14 | ENSP00000370546 | ENSP00000323720 | Arylsulfatase D. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.701 |
ARSD | PRKX | ENSP00000370546 | ENSP00000262848 | Arylsulfatase D. | cAMP-dependent protein kinase catalytic subunit PRKX; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular- like stru [...] | 0.664 |
ARSD | SUMF1 | ENSP00000370546 | ENSP00000272902 | Arylsulfatase D. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.701 |
ARSD | SUMF2 | ENSP00000370546 | ENSP00000498402 | Arylsulfatase D. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.670 |
ARSD | XG | ENSP00000370546 | ENSP00000494087 | Arylsulfatase D. | Xg glycoprotein; Belongs to the CD99 family. | 0.776 |
ARSI | ARSD | ENSP00000333395 | ENSP00000370546 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | Arylsulfatase D. | 0.650 |
ARSI | ARSJ | ENSP00000333395 | ENSP00000320219 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | Arylsulfatase family member J. | 0.457 |
ARSI | ARSK | ENSP00000333395 | ENSP00000369346 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | Arylsulfatase family member K. | 0.911 |
ARSI | MED14 | ENSP00000333395 | ENSP00000323720 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.505 |
ARSI | SUMF1 | ENSP00000333395 | ENSP00000272902 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.759 |
ARSI | SUMF2 | ENSP00000333395 | ENSP00000498402 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.694 |
ARSJ | ARSD | ENSP00000320219 | ENSP00000370546 | Arylsulfatase family member J. | Arylsulfatase D. | 0.638 |
ARSJ | ARSI | ENSP00000320219 | ENSP00000333395 | Arylsulfatase family member J. | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. | 0.457 |
ARSJ | ARSK | ENSP00000320219 | ENSP00000369346 | Arylsulfatase family member J. | Arylsulfatase family member K. | 0.901 |
ARSJ | MED14 | ENSP00000320219 | ENSP00000323720 | Arylsulfatase family member J. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.505 |