node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf86 | ZZEF1 | ENSP00000311479 | ENSP00000371051 | Uncharacterized protein C11orf86; Chromosome 11 open reading frame 86. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.522 |
CCDC58 | KATNBL1 | ENSP00000291458 | ENSP00000256544 | Coiled-coil domain containing 58; Belongs to the CCDC58 family. | KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. | 0.572 |
CCDC58 | ZZEF1 | ENSP00000291458 | ENSP00000371051 | Coiled-coil domain containing 58; Belongs to the CCDC58 family. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.531 |
CLEC16A | ZZEF1 | ENSP00000387122 | ENSP00000371051 | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.535 |
EPG5 | TAF1 | ENSP00000282041 | ENSP00000406549 | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located. | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | 0.466 |
EPG5 | ZZEF1 | ENSP00000282041 | ENSP00000371051 | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.493 |
FTSJ3 | ZZEF1 | ENSP00000396673 | ENSP00000371051 | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.560 |
KATNBL1 | CCDC58 | ENSP00000256544 | ENSP00000291458 | KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. | Coiled-coil domain containing 58; Belongs to the CCDC58 family. | 0.572 |
KATNBL1 | ZZEF1 | ENSP00000256544 | ENSP00000371051 | KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.531 |
TAF1 | EPG5 | ENSP00000406549 | ENSP00000282041 | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located. | 0.466 |
TAF1 | ZZEF1 | ENSP00000406549 | ENSP00000371051 | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.486 |
VPS13D | ZZEF1 | ENSP00000478104 | ENSP00000371051 | Vacuolar protein sorting-associated protein 13D; Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.485 |
ZCCHC14 | ZZEF1 | ENSP00000268616 | ENSP00000371051 | Zinc finger CCHC-type containing 14. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.530 |
ZSWIM8 | ZZEF1 | ENSP00000381693 | ENSP00000371051 | Zinc finger SWIM-type containing 8. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.582 |
ZZEF1 | C11orf86 | ENSP00000371051 | ENSP00000311479 | Zinc finger ZZ-type and EF-hand domain containing 1. | Uncharacterized protein C11orf86; Chromosome 11 open reading frame 86. | 0.522 |
ZZEF1 | CCDC58 | ENSP00000371051 | ENSP00000291458 | Zinc finger ZZ-type and EF-hand domain containing 1. | Coiled-coil domain containing 58; Belongs to the CCDC58 family. | 0.531 |
ZZEF1 | CLEC16A | ENSP00000371051 | ENSP00000387122 | Zinc finger ZZ-type and EF-hand domain containing 1. | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family. | 0.535 |
ZZEF1 | EPG5 | ENSP00000371051 | ENSP00000282041 | Zinc finger ZZ-type and EF-hand domain containing 1. | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located. | 0.493 |
ZZEF1 | FTSJ3 | ENSP00000371051 | ENSP00000396673 | Zinc finger ZZ-type and EF-hand domain containing 1. | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | 0.560 |
ZZEF1 | KATNBL1 | ENSP00000371051 | ENSP00000256544 | Zinc finger ZZ-type and EF-hand domain containing 1. | KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. | 0.531 |