node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
INSL3 | INSL4 | ENSP00000369017 | ENSP00000239316 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | 0.908 |
INSL3 | INSL5 | ENSP00000369017 | ENSP00000302724 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family. | 0.965 |
INSL3 | INSL6 | ENSP00000369017 | ENSP00000371054 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | 0.704 |
INSL3 | RLN3 | ENSP00000369017 | ENSP00000397415 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family. | 0.985 |
INSL3 | RXFP1 | ENSP00000369017 | ENSP00000405841 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Belongs to the G-protein coupled receptor 1 family. | 0.997 |
INSL3 | RXFP2 | ENSP00000369017 | ENSP00000298386 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). | 0.999 |
INSL3 | RXFP3 | ENSP00000369017 | ENSP00000328708 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. | 0.914 |
INSL3 | RXFP4 | ENSP00000369017 | ENSP00000357301 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family. | 0.906 |
INSL4 | INSL3 | ENSP00000239316 | ENSP00000369017 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | 0.908 |
INSL4 | INSL5 | ENSP00000239316 | ENSP00000302724 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family. | 0.663 |
INSL4 | INSL6 | ENSP00000239316 | ENSP00000371054 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | 0.979 |
INSL4 | RLN3 | ENSP00000239316 | ENSP00000397415 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family. | 0.715 |
INSL4 | RXFP1 | ENSP00000239316 | ENSP00000405841 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Belongs to the G-protein coupled receptor 1 family. | 0.582 |
INSL4 | RXFP2 | ENSP00000239316 | ENSP00000298386 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). | 0.574 |
INSL4 | RXFP3 | ENSP00000239316 | ENSP00000328708 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. | 0.596 |
INSL4 | RXFP4 | ENSP00000239316 | ENSP00000357301 | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family. | 0.599 |
INSL5 | INSL3 | ENSP00000302724 | ENSP00000369017 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family. | 0.965 |
INSL5 | INSL4 | ENSP00000302724 | ENSP00000239316 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family. | Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family. | 0.663 |
INSL5 | INSL6 | ENSP00000302724 | ENSP00000371054 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family. | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | 0.743 |
INSL5 | RLN3 | ENSP00000302724 | ENSP00000397415 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family. | 0.997 |