node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRDC5 | C11orf94 | ENSP00000371200 | ENSP00000401498 | Arrestin domain containing 5; Belongs to the arrestin family. | Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94. | 0.475 |
ARRDC5 | C4orf17 | ENSP00000371200 | ENSP00000322582 | Arrestin domain containing 5; Belongs to the arrestin family. | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17. | 0.507 |
ARRDC5 | CXorf65 | ENSP00000371200 | ENSP00000363369 | Arrestin domain containing 5; Belongs to the arrestin family. | Uncharacterized protein CXorf65; Chromosome X open reading frame 65. | 0.478 |
ARRDC5 | LKAAEAR1 | ENSP00000371200 | ENSP00000310801 | Arrestin domain containing 5; Belongs to the arrestin family. | Protein LKAAEAR1; LKAAEAR motif containing 1. | 0.611 |
ARRDC5 | NEDD4 | ENSP00000371200 | ENSP00000424827 | Arrestin domain containing 5; Belongs to the arrestin family. | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | 0.672 |
ARRDC5 | NEDD4L | ENSP00000371200 | ENSP00000383199 | Arrestin domain containing 5; Belongs to the arrestin family. | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and [...] | 0.579 |
ARRDC5 | TEX38 | ENSP00000371200 | ENSP00000455854 | Arrestin domain containing 5; Belongs to the arrestin family. | Testis-expressed protein 38; Testis expressed 38. | 0.489 |
ARRDC5 | TXNIP | ENSP00000371200 | ENSP00000462521 | Arrestin domain containing 5; Belongs to the arrestin family. | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor c [...] | 0.592 |
ARRDC5 | VPS26C | ENSP00000371200 | ENSP00000311399 | Arrestin domain containing 5; Belongs to the arrestin family. | Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of nu [...] | 0.493 |
ARRDC5 | WWP2 | ENSP00000371200 | ENSP00000352069 | Arrestin domain containing 5; Belongs to the arrestin family. | NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T- cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiqu [...] | 0.616 |
C11orf94 | ARRDC5 | ENSP00000401498 | ENSP00000371200 | Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94. | Arrestin domain containing 5; Belongs to the arrestin family. | 0.475 |
C11orf94 | TEX38 | ENSP00000401498 | ENSP00000455854 | Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94. | Testis-expressed protein 38; Testis expressed 38. | 0.545 |
C4orf17 | ARRDC5 | ENSP00000322582 | ENSP00000371200 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17. | Arrestin domain containing 5; Belongs to the arrestin family. | 0.507 |
C4orf17 | LKAAEAR1 | ENSP00000322582 | ENSP00000310801 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17. | Protein LKAAEAR1; LKAAEAR motif containing 1. | 0.670 |
CXorf65 | ARRDC5 | ENSP00000363369 | ENSP00000371200 | Uncharacterized protein CXorf65; Chromosome X open reading frame 65. | Arrestin domain containing 5; Belongs to the arrestin family. | 0.478 |
LKAAEAR1 | ARRDC5 | ENSP00000310801 | ENSP00000371200 | Protein LKAAEAR1; LKAAEAR motif containing 1. | Arrestin domain containing 5; Belongs to the arrestin family. | 0.611 |
LKAAEAR1 | C4orf17 | ENSP00000310801 | ENSP00000322582 | Protein LKAAEAR1; LKAAEAR motif containing 1. | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17. | 0.670 |
NEDD4 | ARRDC5 | ENSP00000424827 | ENSP00000371200 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | Arrestin domain containing 5; Belongs to the arrestin family. | 0.672 |
NEDD4 | NEDD4L | ENSP00000424827 | ENSP00000383199 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and [...] | 0.972 |
NEDD4 | TXNIP | ENSP00000424827 | ENSP00000462521 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor c [...] | 0.471 |