node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLN3 | CTNS | ENSP00000454229 | ENSP00000371294 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | 0.621 |
CLN3 | IDUA | ENSP00000454229 | ENSP00000247933 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | alpha-L-iduronidase. | 0.400 |
CTNS | CLN3 | ENSP00000371294 | ENSP00000454229 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.621 |
CTNS | FGGY | ENSP00000371294 | ENSP00000360262 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family. | 0.719 |
CTNS | HS1BP3 | ENSP00000371294 | ENSP00000305193 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.763 |
CTNS | IDUA | ENSP00000371294 | ENSP00000247933 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | alpha-L-iduronidase. | 0.520 |
CTNS | SHPK | ENSP00000371294 | ENSP00000225519 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism. | 0.978 |
CTNS | SLC17A5 | ENSP00000371294 | ENSP00000348019 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. Belongs to the major facilitator [...] | 0.554 |
CTNS | SLC66A1 | ENSP00000371294 | ENSP00000364295 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. | 0.837 |
CTNS | TNNI3 | ENSP00000371294 | ENSP00000341838 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.621 |
CTNS | TNNT2 | ENSP00000371294 | ENSP00000499593 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.594 |
CTNS | TRPV1 | ENSP00000371294 | ENSP00000459962 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] | 0.727 |
FGGY | CTNS | ENSP00000360262 | ENSP00000371294 | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family. | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | 0.719 |
FGGY | SHPK | ENSP00000360262 | ENSP00000225519 | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family. | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism. | 0.879 |
HS1BP3 | CTNS | ENSP00000305193 | ENSP00000371294 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | 0.763 |
IDUA | CLN3 | ENSP00000247933 | ENSP00000454229 | alpha-L-iduronidase. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.400 |
IDUA | CTNS | ENSP00000247933 | ENSP00000371294 | alpha-L-iduronidase. | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | 0.520 |
SHPK | CTNS | ENSP00000225519 | ENSP00000371294 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism. | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | 0.978 |
SHPK | FGGY | ENSP00000225519 | ENSP00000360262 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism. | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family. | 0.879 |
SHPK | TRPV1 | ENSP00000225519 | ENSP00000459962 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism. | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] | 0.549 |