TMEM74B protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Score

TMEM74B

Transmembrane protein 74B. (256 aa)

Predicted Functional Partners:

SPINK14

0.604

TRIML2

0.489

TMEM61

0.474

DDX39A

0.467

GPR87

0.461

TMEM239

0.438

OTUD6A

0.437

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX39A	TMEM74B	ENSP00000242776	ENSP00000371318	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	Transmembrane protein 74B.	0.467
GPR87	SPINK14	ENSP00000260843	ENSP00000349459	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family.	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	0.475
GPR87	TMEM74B	ENSP00000260843	ENSP00000371318	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family.	Transmembrane protein 74B.	0.461
OTUD6A	SPINK14	ENSP00000339389	ENSP00000349459	OTU domain-containing protein 6A; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	0.461
OTUD6A	TMEM74B	ENSP00000339389	ENSP00000371318	OTU domain-containing protein 6A; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.	Transmembrane protein 74B.	0.437
SPINK14	GPR87	ENSP00000349459	ENSP00000260843	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family.	0.475
SPINK14	OTUD6A	ENSP00000349459	ENSP00000339389	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	OTU domain-containing protein 6A; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.	0.461
SPINK14	TMEM74B	ENSP00000349459	ENSP00000371318	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	Transmembrane protein 74B.	0.604
SPINK14	TRIML2	ENSP00000349459	ENSP00000422581	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2.	0.503
TMEM239	TMEM61	ENSP00000354312	ENSP00000360315	Transmembrane protein 239.	Transmembrane protein 61.	0.435
TMEM239	TMEM74B	ENSP00000354312	ENSP00000371318	Transmembrane protein 239.	Transmembrane protein 74B.	0.438
TMEM61	TMEM239	ENSP00000360315	ENSP00000354312	Transmembrane protein 61.	Transmembrane protein 239.	0.435
TMEM61	TMEM74B	ENSP00000360315	ENSP00000371318	Transmembrane protein 61.	Transmembrane protein 74B.	0.474
TMEM74B	DDX39A	ENSP00000371318	ENSP00000242776	Transmembrane protein 74B.	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	0.467
TMEM74B	GPR87	ENSP00000371318	ENSP00000260843	Transmembrane protein 74B.	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family.	0.461
TMEM74B	OTUD6A	ENSP00000371318	ENSP00000339389	Transmembrane protein 74B.	OTU domain-containing protein 6A; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.	0.437
TMEM74B	SPINK14	ENSP00000371318	ENSP00000349459	Transmembrane protein 74B.	Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.	0.604
TMEM74B	TMEM239	ENSP00000371318	ENSP00000354312	Transmembrane protein 74B.	Transmembrane protein 239.	0.438
TMEM74B	TMEM61	ENSP00000371318	ENSP00000360315	Transmembrane protein 74B.	Transmembrane protein 61.	0.474
TMEM74B	TRIML2	ENSP00000371318	ENSP00000422581	Transmembrane protein 74B.	Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2.	0.489