TMEM156 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB2	N4BP2	ENSP00000427211	ENSP00000261435	Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein.	NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	0.425
APBB2	RBM47	ENSP00000427211	ENSP00000295971	Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein.	RNA binding motif protein 47; Belongs to the RRM RBM47 family.	0.412
APBB2	TMEM156	ENSP00000427211	ENSP00000371364	Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein.	Transmembrane protein 156.	0.479
IL18BP	TMEM156	ENSP00000434717	ENSP00000371364	Interleukin-18-binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.	Transmembrane protein 156.	0.496
KLHL5	LIAS	ENSP00000423897	ENSP00000492260	Kelch-like protein 5; Kelch like family member 5.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.484
KLHL5	N4BP2	ENSP00000423897	ENSP00000261435	Kelch-like protein 5; Kelch like family member 5.	NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	0.509
KLHL5	RFC1	ENSP00000423897	ENSP00000371321	Kelch-like protein 5; Kelch like family member 5.	Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.	0.461
KLHL5	RPL9	ENSP00000423897	ENSP00000494697	Kelch-like protein 5; Kelch like family member 5.	Ribosomal protein L9.	0.447
KLHL5	SMIM14	ENSP00000423897	ENSP00000295958	Kelch-like protein 5; Kelch like family member 5.	Small integral membrane protein 14.	0.411
KLHL5	TMEM156	ENSP00000423897	ENSP00000371364	Kelch-like protein 5; Kelch like family member 5.	Transmembrane protein 156.	0.645
KLHL5	WDR19	ENSP00000423897	ENSP00000382717	Kelch-like protein 5; Kelch like family member 5.	WD repeat-containing protein 19; As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport (By similarity).	0.567
LIAS	KLHL5	ENSP00000492260	ENSP00000423897	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Kelch-like protein 5; Kelch like family member 5.	0.484
LIAS	N4BP2	ENSP00000492260	ENSP00000261435	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	0.458
LIAS	RPL9	ENSP00000492260	ENSP00000494697	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Ribosomal protein L9.	0.425
LIAS	SMIM14	ENSP00000492260	ENSP00000295958	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Small integral membrane protein 14.	0.519
LIAS	TMEM156	ENSP00000492260	ENSP00000371364	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Transmembrane protein 156.	0.495
LIAS	WDR19	ENSP00000492260	ENSP00000382717	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	WD repeat-containing protein 19; As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport (By similarity).	0.478
N4BP2	APBB2	ENSP00000261435	ENSP00000427211	NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein.	0.425
N4BP2	KLHL5	ENSP00000261435	ENSP00000423897	NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	Kelch-like protein 5; Kelch like family member 5.	0.509
N4BP2	LIAS	ENSP00000261435	ENSP00000492260	NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.458