node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | C1QTNF3 | ENSP00000451828 | ENSP00000371497 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | 0.498 |
AKT1 | HSPB3 | ENSP00000451828 | ENSP00000303394 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | Heat shock protein beta-3; Inhibitor of actin polymerization. | 0.923 |
AKT1 | INS | ENSP00000451828 | ENSP00000380432 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.953 |
AKT1 | LEP | ENSP00000451828 | ENSP00000312652 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.825 |
AKT1 | LY96 | ENSP00000451828 | ENSP00000284818 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. | 0.671 |
AKT1 | SCARB2 | ENSP00000451828 | ENSP00000264896 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. | 0.588 |
C1QTNF12 | C1QTNF3 | ENSP00000329137 | ENSP00000371497 | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | 0.603 |
C1QTNF3 | AKT1 | ENSP00000371497 | ENSP00000451828 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] | 0.498 |
C1QTNF3 | C1QTNF12 | ENSP00000371497 | ENSP00000329137 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | 0.603 |
C1QTNF3 | COLGALT2 | ENSP00000371497 | ENSP00000354960 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen; Belongs to the glycosyltransferase 25 family. | 0.599 |
C1QTNF3 | ERFE | ENSP00000371497 | ENSP00000442304 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Belongs to the adipolin/erythroferrone family. | 0.478 |
C1QTNF3 | HSPB3 | ENSP00000371497 | ENSP00000303394 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Heat shock protein beta-3; Inhibitor of actin polymerization. | 0.657 |
C1QTNF3 | INS | ENSP00000371497 | ENSP00000380432 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.544 |
C1QTNF3 | LEP | ENSP00000371497 | ENSP00000312652 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.635 |
C1QTNF3 | LY96 | ENSP00000371497 | ENSP00000284818 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. | 0.468 |
C1QTNF3 | PLOD2 | ENSP00000371497 | ENSP00000282903 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | 0.469 |
C1QTNF3 | SCARB2 | ENSP00000371497 | ENSP00000264896 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. | 0.467 |
COLGALT2 | C1QTNF3 | ENSP00000354960 | ENSP00000371497 | Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen; Belongs to the glycosyltransferase 25 family. | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | 0.599 |
COLGALT2 | PLOD2 | ENSP00000354960 | ENSP00000282903 | Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen; Belongs to the glycosyltransferase 25 family. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | 0.957 |
ERFE | C1QTNF3 | ENSP00000442304 | ENSP00000371497 | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Belongs to the adipolin/erythroferrone family. | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3. | 0.478 |