node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHCHD7 | LCORL | ENSP00000306425 | ENSP00000371661 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.548 |
CHCHD7 | NCAPG | ENSP00000306425 | ENSP00000251496 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.503 |
CHCHD7 | PLAG1 | ENSP00000306425 | ENSP00000325546 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Zinc finger protein PLAG1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepat [...] | 0.947 |
CLCN2 | LCORL | ENSP00000265593 | ENSP00000371661 | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage- gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.579 |
CTBP1 | LCORL | ENSP00000290921 | ENSP00000371661 | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.860 |
DCAF16 | FAM184B | ENSP00000371682 | ENSP00000265018 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.759 |
DCAF16 | LCORL | ENSP00000371682 | ENSP00000371661 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.716 |
DCAF16 | NCAPG | ENSP00000371682 | ENSP00000251496 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.723 |
FAM184B | DCAF16 | ENSP00000265018 | ENSP00000371682 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | 0.759 |
FAM184B | LAP3 | ENSP00000265018 | ENSP00000226299 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Belongs to the peptidase M17 family. | 0.441 |
FAM184B | LCORL | ENSP00000265018 | ENSP00000371661 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.777 |
FAM184B | NCAPG | ENSP00000265018 | ENSP00000251496 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.747 |
FAM184B | PLAG1 | ENSP00000265018 | ENSP00000325546 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Zinc finger protein PLAG1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepat [...] | 0.412 |
HMGA2 | LCORL | ENSP00000437621 | ENSP00000371661 | High mobility group AT-hook 2. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.586 |
HMGA2 | NCAPG | ENSP00000437621 | ENSP00000251496 | High mobility group AT-hook 2. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.547 |
HMGA2 | PLAG1 | ENSP00000437621 | ENSP00000325546 | High mobility group AT-hook 2. | Zinc finger protein PLAG1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepat [...] | 0.823 |
HMGA2 | ZFAT | ENSP00000437621 | ENSP00000367069 | High mobility group AT-hook 2. | Zinc finger protein ZFAT; May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). | 0.456 |
LAP3 | FAM184B | ENSP00000226299 | ENSP00000265018 | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Belongs to the peptidase M17 family. | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.441 |
LAP3 | LCORL | ENSP00000226299 | ENSP00000371661 | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Belongs to the peptidase M17 family. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.613 |
LAP3 | NCAPG | ENSP00000226299 | ENSP00000251496 | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Belongs to the peptidase M17 family. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.538 |