STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ZDHHC20Palmitoyltransferase ZDHHC20; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. Belongs to the DHHC palmitoyltransferase family. (365 aa)    
Predicted Functional Partners:
GOLGA7
Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
   
 
 0.681
ZDHHC5
Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).
   
 
0.600
ZDHHC3
Palmitoyltransferase ZDHHC3; Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).
   
 
0.592
EEF1AKMT1
EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
   
  
 0.584
ZDHHC9
Palmitoyltransferase ZDHHC9; The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
     
0.566
ZDHHC8
Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
     
0.555
ZDHHC11
Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family.
     
0.551
ZDHHC22
Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity).
      
 0.520
MBLAC2
Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
   
 
 0.472
GOLGA7B
Golgin subfamily A member 7B; May be involved in protein transport from Golgi to cell surface; Belongs to the ERF4 family.
      
 0.464
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.