TMEM241 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD29	GREB1L	ENSP00000468354	ENSP00000464162	Ankyrin repeat domain 29.	GREB1-like protein; Plays a major role in early metanephros and genital development.	0.478
ANKRD29	TMEM241	ENSP00000468354	ENSP00000372720	Ankyrin repeat domain 29.	Transmembrane protein 241.	0.580
CABLES1	THOC1	ENSP00000256925	ENSP00000261600	CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).	THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...]	0.404
CABLES1	TMEM241	ENSP00000256925	ENSP00000372720	CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).	Transmembrane protein 241.	0.508
CNNM2	TMEM241	ENSP00000358894	ENSP00000372720	Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).	Transmembrane protein 241.	0.436
DNPH1	TMEM241	ENSP00000230431	ENSP00000372720	2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases; Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.	Transmembrane protein 241.	0.438
GREB1L	ANKRD29	ENSP00000464162	ENSP00000468354	GREB1-like protein; Plays a major role in early metanephros and genital development.	Ankyrin repeat domain 29.	0.478
GREB1L	TMEM241	ENSP00000464162	ENSP00000372720	GREB1-like protein; Plays a major role in early metanephros and genital development.	Transmembrane protein 241.	0.478
RIOK2	TMEM241	ENSP00000283109	ENSP00000372720	Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function.	Transmembrane protein 241.	0.460
SLC35E4	TMEM144	ENSP00000339626	ENSP00000296529	Solute carrier family 35 member E4; Putative transporter.	Transmembrane protein 144; Belongs to the TMEM144 family.	0.512
SLC35E4	TMEM234	ENSP00000339626	ENSP00000309792	Solute carrier family 35 member E4; Putative transporter.	Transmembrane protein 234; Belongs to the TMEM234 family.	0.579
SLC35E4	TMEM241	ENSP00000339626	ENSP00000372720	Solute carrier family 35 member E4; Putative transporter.	Transmembrane protein 241.	0.582
THOC1	CABLES1	ENSP00000261600	ENSP00000256925	THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...]	CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).	0.404
THOC1	TMEM241	ENSP00000261600	ENSP00000372720	THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...]	Transmembrane protein 241.	0.451
TMEM144	SLC35E4	ENSP00000296529	ENSP00000339626	Transmembrane protein 144; Belongs to the TMEM144 family.	Solute carrier family 35 member E4; Putative transporter.	0.512
TMEM144	TMEM234	ENSP00000296529	ENSP00000309792	Transmembrane protein 144; Belongs to the TMEM144 family.	Transmembrane protein 234; Belongs to the TMEM234 family.	0.573
TMEM144	TMEM241	ENSP00000296529	ENSP00000372720	Transmembrane protein 144; Belongs to the TMEM144 family.	Transmembrane protein 241.	0.502
TMEM234	SLC35E4	ENSP00000309792	ENSP00000339626	Transmembrane protein 234; Belongs to the TMEM234 family.	Solute carrier family 35 member E4; Putative transporter.	0.579
TMEM234	TMEM144	ENSP00000309792	ENSP00000296529	Transmembrane protein 234; Belongs to the TMEM234 family.	Transmembrane protein 144; Belongs to the TMEM144 family.	0.573
TMEM234	TMEM241	ENSP00000309792	ENSP00000372720	Transmembrane protein 234; Belongs to the TMEM234 family.	Transmembrane protein 241.	0.549