node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC166 | FOXI2 | ENSP00000437468 | ENSP00000373572 | Coiled-coil domain containing 166. | Forkhead box protein I2; Possible transcriptional activator. | 0.414 |
DLX5 | FOXG1 | ENSP00000498116 | ENSP00000339004 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL an [...] | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | 0.657 |
DLX5 | FOXI2 | ENSP00000498116 | ENSP00000373572 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL an [...] | Forkhead box protein I2; Possible transcriptional activator. | 0.414 |
FOXG1 | DLX5 | ENSP00000339004 | ENSP00000498116 | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL an [...] | 0.657 |
FOXG1 | FOXI2 | ENSP00000339004 | ENSP00000373572 | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | Forkhead box protein I2; Possible transcriptional activator. | 0.424 |
FOXG1 | FOXN3 | ENSP00000339004 | ENSP00000343288 | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). | 0.411 |
FOXG1 | VAX1 | ENSP00000339004 | ENSP00000358207 | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity); Belongs to the EMX homeobox family. | 0.402 |
FOXI2 | CCDC166 | ENSP00000373572 | ENSP00000437468 | Forkhead box protein I2; Possible transcriptional activator. | Coiled-coil domain containing 166. | 0.414 |
FOXI2 | DLX5 | ENSP00000373572 | ENSP00000498116 | Forkhead box protein I2; Possible transcriptional activator. | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL an [...] | 0.414 |
FOXI2 | FOXG1 | ENSP00000373572 | ENSP00000339004 | Forkhead box protein I2; Possible transcriptional activator. | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | 0.424 |
FOXI2 | FOXN3 | ENSP00000373572 | ENSP00000343288 | Forkhead box protein I2; Possible transcriptional activator. | Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). | 0.467 |
FOXI2 | FOXR2 | ENSP00000373572 | ENSP00000427329 | Forkhead box protein I2; Possible transcriptional activator. | Forkhead box R2. | 0.450 |
FOXI2 | SEPTIN12 | ENSP00000373572 | ENSP00000268231 | Forkhead box protein I2; Possible transcriptional activator. | Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPa [...] | 0.405 |
FOXI2 | SEPTIN9 | ENSP00000373572 | ENSP00000391249 | Forkhead box protein I2; Possible transcriptional activator. | Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.481 |
FOXI2 | VAX1 | ENSP00000373572 | ENSP00000358207 | Forkhead box protein I2; Possible transcriptional activator. | Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity); Belongs to the EMX homeobox family. | 0.471 |
FOXI2 | ZNF471 | ENSP00000373572 | ENSP00000309161 | Forkhead box protein I2; Possible transcriptional activator. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.409 |
FOXI2 | ZSCAN18 | ENSP00000373572 | ENSP00000470123 | Forkhead box protein I2; Possible transcriptional activator. | Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation. | 0.425 |
FOXN3 | FOXG1 | ENSP00000343288 | ENSP00000339004 | Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. | 0.411 |
FOXN3 | FOXI2 | ENSP00000343288 | ENSP00000373572 | Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). | Forkhead box protein I2; Possible transcriptional activator. | 0.467 |
FOXN3 | FOXR2 | ENSP00000343288 | ENSP00000427329 | Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). | Forkhead box R2. | 0.414 |